Evidence map›Paper›PMID 30191351›Full record

ArticleEJNMMI research2018

PET imaging of chemokine receptor CXCR4 in patients with primary and recurrent breast carcinoma.

Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske, Peter Herhaus, Johannes Ettl, Markus Niemeyer, Hans-Jürgen Wester, Markus Schwaiger

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Development of an Optimized CXCR4-Targeting Theranostic Pair.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Review
  4. Review
  5. ComparingCancers · 2025
    Article
  6. Review
  7. Review
  8. Advances in PET Imaging of the CXCR4 Receptor: [Seminars in nuclear medicine · 2024
    Review
  9. Review
  10. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  11. The Role of PET/CT in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  12. [Asia Oceania journal of nuclear medicine & biology · 2023
    Article
  13. [Cells · 2022
    Article
  14. Current Status ofDiagnostics (Basel, Switzerland) · 2022
    Review
  15. Review
  16. Review
  17. Potential for Increasing Uptake of RadiolabeledCancer biotherapy & radiopharmaceuticals · 2021
    Article
  18. Novel Agents and Future Perspectives on Theranostics.Seminars in radiation oncology · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tibor VagClinic of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. tibor.vag@tum.de.ORCID http://orcid.org/0000-0002-9004-7683
Katja SteigerInstitute of Pathology, Technische Universität München, Troger Strasse 18, 81675, Munich, Germany.
Andreas RossmannClinic of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Ulrich KellerIII Medical Department, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Aurelia NoskeInstitute of Pathology, Technische Universität München, Troger Strasse 18, 81675, Munich, Germany.
Peter HerhausIII Medical Department, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Johannes EttlClinic of Gynecology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Markus NiemeyerClinic of Gynecology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technische Universität München, Walther-Meissner Strasse 3, 85748, Garching, Germany.
Markus SchwaigerClinic of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
TUM Klinikum · DETechnical University of Munich · DE

Funding

Deutsche Forschungsgemeinschaft SFB 824
6 · The paper itself

Abstract

backgroundCXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis was to assess the diagnostic performance of CXCR4-directed PET imaging in patients with breast cancer using the recently introduced CXCR4-targeted PET probe

resultsThirteen patients with first diagnosis of breast cancer, four patients with recurrent disease after primary breast cancer, and one patient with axillary lymph node metastasis of unknown primary underwent CXCR4-targeted PET imaging using

conclusionsCXCR4-directed PET imaging in patients with primary and recurrent breast cancer is feasible; however, tumor detectability is significantly lower compared to

Indexed as

Breast cancerChemokine receptorCXCR4Positron emission tomography

Identifiers

PMID30191351
PMCPMC6127070
OpenAlexW2891400199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.