Evidence map›Paper›PMID 30191336›Full record

ArticleBasic research in cardiology2018

Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress.

Andrey Kazakov, Rabea A Hall, Christian Werner, Timo Meier, André Trouvain, Svetlana Rodionycheva, Alexander Nickel, Frank Lammert, Christoph Maack, Michael Böhm and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Basic research in cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Heart failure, inflammation and exercise.International journal of biological sciences · 2025
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  9. NRF2 in Cardiovascular Diseases: a Ray of Hope!Journal of cardiovascular translational research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrey KazakovKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, IMED, 66421, Homburg, Germany. Andrej.Kasakow@uks.eu.ORCID http://orcid.org/0000-0002-3031-0240
Rabea A HallKlinik für Innere Medizin II, Gastroenterologie, Hepatologie, Endokrinologie, Diabetologie und Ernährungsmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 77, 66421, Homburg, Germany.
Christian WernerKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, IMED, 66421, Homburg, Germany.
Timo MeierKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, IMED, 66421, Homburg, Germany.
André TrouvainKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, IMED, 66421, Homburg, Germany.
Svetlana RodionychevaKlinik für Thorax- und Herz-Gefäßchirurgie, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 57, 66421, Homburg, Germany.
Alexander NickelDeutsches Zentrum für Herzinsuffizienz, Universitätsklinikum Würzburg, am Schwarzenberg 15, A15, 97078, Würzburg, Germany.
Frank LammertKlinik für Innere Medizin II, Gastroenterologie, Hepatologie, Endokrinologie, Diabetologie und Ernährungsmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 77, 66421, Homburg, Germany.
Christoph MaackDeutsches Zentrum für Herzinsuffizienz, Universitätsklinikum Würzburg, am Schwarzenberg 15, A15, 97078, Würzburg, Germany.
Michael BöhmKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität/Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, IMED, 66421, Homburg, Germany.
Ulrich LaufsKlinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Universitätsklinikum des Saarlandes · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Leipzig · DE

Funding

BMBF LiSyM 031L0051Corona foundation s199/10060/2014Deutsche Forschungsgemeinschaft Heisenberg-ProgrammDeutsche Forschungsgemeinschaft KA4024/3-1Deutsche Forschungsgemeinschaft Ma2528/7-1Deutsche Forschungsgemeinschaft SFB-9894Deutsche Forschungsgemeinschaft SFB TRP219Dr. Marija Orlovic Stiftung 2016Universität des Saarlandes HOMFOR
6 · The paper itself

Abstract

Fibrosis is a hallmark of maladaptive cardiac remodelling. Here we report that genome-wide quantitative trait locus (QTL) analyses in recombinant inbred mouse lines of C57BL/6 J and DBA2/J strains identified Raf Kinase Inhibitor Protein (RKIP) as genetic marker of fibrosis progression. C57BL/6 N-RKIP

Indexed as

Oxidative StressVentricular Function, LeftVentricular RemodelingAnimalsApoptosisCardiomyopathiesCell MovementCell ProliferationCells, CulturedDisease Models, AnimalFibroblastsFibronectinsFibrosisHeart FailureHumansMice, Inbred C57BLFibronectinsMitochondrial ProteinsNADP Transhydrogenase, AB-SpecificNfe2l2 protein, mouseNF-E2-Related Factor 2Nnt protein, mousePhosphatidylethanolamine Binding ProteinRaf kinase inhibitory protein, mouseCardiac fibrosisNrf2Oxidative stressRKIP

Identifiers

PMID30191336
PMCPMC6133069
OpenAlexW2891290659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.