Evidence map›Paper›PMID 30191314›Full record

ArticleInternational journal of legal medicine2019

Multiplex analysis of genetic polymorphisms within UGT1A9, a gene involved in phase II of Δ

Julia Sophie Schneider, Angela Gasse, Marianne Schürenkamp, Ursula Sibbing, Sabrina Banken, Heidi Pfeiffer, Jennifer Schürenkamp, Marielle Vennemann

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of legal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Julia Sophie SchneiderInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Angela GasseInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Marianne SchürenkampInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Ursula SibbingInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Sabrina BankenInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Heidi PfeifferInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
Jennifer SchürenkampInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany. Jennifer.schuerenkamp@ukmuenster.de.
Marielle VennemannInstitute of Legal Medicine, University of Münster, Röntgenstraße 23, 48149, Münster, Germany.
University of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a novel multiplex assay for the simultaneous detection of 12 polymorphisms within the UGT1A9 sequence, which codes for enzymes involved in phase II biotransformation. The assay combines a multiplexed amplification step with single-base extension sequencing. The method described here is fast, cost-effective, and easy-to-use, combining the relevant features of screening methods for research and diagnostics in pharmacogenetics. To validate the assay, we tested reproducibility and sensitivity and analysed allele frequencies of 110 Caucasian individuals. Furthermore, we describe combining genetic information of individuals consuming Cannabis sativa products with respective plasma concentrations of a metabolite.

Indexed as

Polymorphism, GeneticAdolescentAdultDronabinolFemaleForensic ToxicologyGene FrequencyGlucuronosyltransferaseHaplotypesHumansMaleMiddle AgedPharmacogenomic VariantsPolymerase Chain ReactionPsychotropic DrugsReproducibility of ResultsDronabinolGlucuronosyltransferasePsychotropic DrugsUDP-Glucuronosyltransferase 1A9UGT1A9 protein, humanBiological assayCannabisDelta(9)-THCPersonalised medicineUDP-glucuronosyltransferase 1A9

Identifiers

PMID30191314
OpenAlexW2889613682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.