Evidence map›Paper›PMID 30191060›Full record

Trial reportF1000Research2018

Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression.

Ilijana Begcevic, Magda Tsolaki, Davor Brinc, Marshall Brown, Eduardo Martinez-Morillo, Ioulietta Lazarou, Mahi Kozori, Fani Tagaraki, Stella Nenopoulou, Mara Gkioka and 4 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  10. Associations between fluid biomarkers and PET imaging ([11C]UCB-J) of synaptic pathology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Ilijana BegcevicDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Magda Tsolaki1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Davor BrincDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Marshall BrownDepartment of Biostatistics, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Eduardo Martinez-MorilloLaboratory of Medicine, Department of Clinical Biochemistry, Hospital Universitario Central, Oviedo, Spain.
Ioulietta Lazarou1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Mahi Kozori1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Fani Tagaraki1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Stella Nenopoulou1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Mara Gkioka1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eutichia Lazarou1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Bryant LimDepartment of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
Ihor BatruchDepartment of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
Eleftherios P DiamandisDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.ORCID 0000-0002-1589-820X
Aristotle University of Thessaloniki · GRMount Sinai Hospital · CAFred Hutch Cancer Center · USHospital Universitario Central de Asturias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersFemaleHumansMalePlaque, AmyloidReceptors, Cell SurfaceRetrospective StudiesAmyloid beta-PeptidesBiomarkersneuronal pentraxin receptorReceptors, Cell SurfaceAlzheimer’s diseaseAlzheimer’s disease progressionbiomarkerscerebrospinal fluiddementiamass spectrometryneuronal pentraxin receptor-1selected reaction monitoring

Identifiers

PMID30191060
PMCPMC6081984
OpenAlexW2848858403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.