ReviewHepatic oncology2015
Biphenotypic (hepatobiliary) primary liver carcinomas: the work in progress.
Review in Hepatic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Radiogenomics deciphers tumor heterogeneity in hepatocellular carcinoma and combined hepatocellular-cholangiocarcinoma.Discover oncology · 2026Article
- A Case of Combined Hepatocellular-Cholangiocarcinoma Diagnosis and Treatment With Literature Review.Clinical case reports · 2025Article
- Liver transplantation for combined hepatocellular cholangiocarcinoma: Current evidence, selection criteria, and therapeutic controversies.World journal of gastrointestinal surgery · 2025Review
- Combined hepatocellular-cholangiocarcinoma: from genesis to molecular pathways and therapeutic strategies.Journal of cancer research and clinical oncology · 2024Review
- Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions.Cell reports. Medicine · 2024Article
- Decreased ARG1 expression as an adverse prognostic phenotype in non-alcoholic non-virus-related hepatocellular carcinoma.Virchows Archiv : an international journal of pathology · 2022Article
- Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach.Biomedicines · 2022Review
- Combined Hepatocellular-Cholangiocarcinoma: Changes in the 2019 World Health Organization Histological Classification System and Potential Impact on Imaging-Based Diagnosis.Korean journal of radiology · 2020Review
- Assessment of primary liver carcinomas other than hepatocellular carcinoma (HCC) with LI-RADS v2018: comparison of the LI-RADS target population to patients without LI-RADS-defined HCC risk factors.European radiology · 2020Observational
- Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma.Frontiers in oncology · 2020Review
- Murine hepatoblast-derived liver tumors resembling human combined hepatocellular-cholangiocarcinoma with stem cell features.Cell & bioscience · 2020Article
- cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.Hepatology (Baltimore, Md.) · 2018Article
- Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.Journal of hepatocellular carcinoma · 2018Review
- Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.Nature medicine · 2017Article
- Look into hepatic progenitor cell associated trait: Histological heterogeneity of hepatitis B-related combined hepatocellular-cholangiocarcinoma.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- Histological heterogeneity in primary and metastatic classic combined hepatocellular-cholangiocarcinoma: a case series.Virchows Archiv : an international journal of pathology · 2017Article
- From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.World journal of gastroenterology · 2017Review
- Pathology of intrahepatic cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2017Review
- Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes.Nature reviews. Gastroenterology & hepatology · 2015Article
- Hepatic stem cells and cancers: a pathologist's view.Hepatic oncology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent WHO classification for combined hepatocellular-cholangiocarcinoma and recognized stem cell subtypes has increased attention to such tumors; however, the resulting burst of reporting and research indicates that this classification, while provocative, is incomplete for description of the full array of primary liver carcinomas with biphenotypic (hepatobiliary) differentiation. We review the history of such lesions and consider the wider array of such tumors previously described. Mixed hepatobiliary phenotypes and immunophenotypes are found in individual tumors at the tissue level - with architectural and cytologic features supportive of both differentiation states - and at the cellular level, with individual cells that display cytology of one cell type, but immunophenotypically showing mixed expression. Pathobiologic and clinical questions to be answered by future research are suggested.
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