ArticleHepatic oncology2015
High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.
Article in Hepatic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Prognostic role of dickkopf-1 in patients with cancer.Medicine · 2020Pooled it
- Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma.Journal for immunotherapy of cancer · 2026Article
- DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.Cancers · 2026Review
- The Dickkopf-1 (DKK1) Dichotomy in Oncology: New Insights on Tumor Progression and Immune Regulation.International journal of molecular sciences · 2026Review
- Review
- In silico identification of the specific pathways in each stage of colorectal cancer and the association of their top genes with drug resistance and sensitivity.Medical oncology (Northwood, London, England) · 2022Article
- A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.Frontiers in oncology · 2022Article
- Article
- A Robust Circular RNA-Associated Three-Gene Prognostic Signature for Patients with Gastric Cancer.BioMed research international · 2021Article
- Serum Tumor Markers for Early Diagnosis of Primary Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2020Review
- Chemoprevention of elite tea variety CFT-1 rich in EGCG against chemically induced liver cancer in rats.Food science & nutrition · 2019Article
- DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway.Cancer cell international · 2019Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate prognostic significance of DKK1 for hepatocelluar carcinoma. MATERIALS &
methodsWe enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model.
resultsHigh levels of preoperative serum DKK1 were associated with poor overall survival and higher recurrence rate and DKK1 was an independent prognostic predictor. Moreover, DKK1 maintained ability to predict recurrence for patients with low recurrence risk. Double positives of DKK1 and AFP indicated the worst overall survival and the highest recurrence rate compared with either used alone. Patients with preoperatively and 1-day postoperatively positive DKK1 had higher recurrence rates than those whose values were both negative. Similar results were found in the validation cohort.
conclusionSerum DKK1 could predict prognosis of hepatocelluar carcinoma after hepatectomy.
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