Evidence map›Paper›PMID 30190913›Full record

ReviewMelanoma management2017

A surgical perspective report on melanoma management.

Brian D Wernick, Neha Goel, Francis Sw Zih, Jeffrey M Farma

Abstract readReview
In one paragraph

Review in Melanoma management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brian D WernickSt. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA.
Neha GoelFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Francis Sw ZihFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Jeffrey M FarmaFox Chase Cancer Center, Philadelphia, PA 19111, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of melanoma includes wide excision with adequate margins and lymph node biopsy depending on the depth of the lesion, with subsequent completion lymphadenectomy for positive sentinel node. Locally advanced disease can be approached in several different ways depending on a variety of patient and disease-specific factors. These include surgical resection, isolated limb perfusion and infusion and intralesional injection therapy such as talimogene laherparepvec, IL-2 and Bacille Calmette-Guerin. Ongoing controversy exists regarding the utility of completion lymphadenectomy, and trials such as MSLT-2 will attempt to shed light on this issue. The future of melanoma management will likely focus on expanding the use of immunotherapy, allowing for narrower surgical margins, particularly in sensitive anatomic areas, and limiting the number of completion lymphadenectomies.

Indexed as

completion lymphadenectomyintralesional injection therapyin-transit diseaseisolated limb infusionisolated limb perfusionmelanomamelanoma in situmelanoma marginssentinel lymph node biopsyT-VEC

Identifiers

PMID30190913
PMCPMC6094622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.