Evidence map›Paper›PMID 30190701›Full record

ReviewFrontiers in neurology2018

Application of Precision Medicine in Neurodegenerative Diseases.

Claudia Strafella, Valerio Caputo, Maria R Galota, Stefania Zampatti, Gianluca Marella, Silvestro Mauriello, Raffaella Cascella, Emiliano Giardina

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Trial
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  16. Article
  17. Tackling neurodegenerationFrontiers in molecular neuroscience · 2024
    Review
  18. Alzheimer's Disease: A Suitable Case for Treatment with Precision Medicine?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia StrafellaDepartment of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Valerio CaputoDepartment of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Maria R GalotaMolecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.
Stefania ZampattiMolecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.
Gianluca MarellaSection of Legal Medicine, Tor Vergata University, Rome, Italy.
Silvestro MaurielloSection of Legal Medicine, Tor Vergata University, Rome, Italy.
Raffaella CascellaMolecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.
Emiliano GiardinaDepartment of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the main challenges for healthcare systems is the increasing prevalence of neurodegenerative pathologies together with the rapidly aging populations. The enormous progresses made in the field of biomedical research and informatics have been crucial for improving the knowledge of how genes, epigenetic modifications, aging, nutrition, drugs and microbiome impact health and disease. In fact, the availability of high technology and computational facilities for large-scale analysis enabled a deeper investigation of neurodegenerative disorders, providing a more comprehensive overview of disease and encouraging the development of a precision medicine approach for these pathologies. On this subject, the creation of collaborative networks among medical centers, research institutes and highly qualified specialists can be decisive for moving the precision medicine from the bench to the bedside. To this purpose, the present review has been thought to discuss the main components which may be part of precise and personalized treatment programs applied to neurodegenerative disorders. Parkinson Disease will be taken as an example to understand how precision medicine approach can be clinically useful and provide substantial benefit to patients. In this perspective, the realization of web-based networks can be decisive for the implementation of precision medicine strategies across different specialized centers as well as for supporting clinical/therapeutical decisions and promoting a more preventive and participative medicine for neurodegenerative disorders. These collaborative networks are essentially addressed to find innovative, sustainable and effective strategies able to provide optimal and safer therapies, discriminate at risk individuals, identify patients at preclinical or early stage of disease, set-up individualized and preventative strategies for improving prognosis and patient's quality of life.

Indexed as

neurodegenerative diseasesomic profilesParkinson diseaseprecision medicineresearch networks

Identifiers

PMID30190701
PMCPMC6115491

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.