ArticleScientific reports2018
Urinary neopterin levels increase and predict survival during a respiratory outbreak in wild chimpanzees (Taï National Park, Côte d'Ivoire).
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations.American journal of biological anthropology · 2026Article
- Taxonomic variation in immune response strategies among primates.Genes and immunity · 2025Review
- Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild.American journal of primatology · 2025Review
- Comparison of age-related inflammation and oxidative stress in two lemur species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Modulation of cell-mediated immunity during pregnancy in wild bonobos.Biology letters · 2024Article
- Neopterin Levels in Bonobos Vary Seasonally and Reflect Symptomatic Respiratory Infections.EcoHealth · 2023Article
- Urinary neopterin reflects immunological variation associated with age, helminth parasitism, and the microbiome in a wild primate.Scientific reports · 2022Article
- A Review of Non-Invasive Sampling in Wildlife Disease and Health Research: What's New?Animals : an open access journal from MDPI · 2022Review
- Validating Urinary Neopterin as a Biomarker of Immune Response in Captive and Wild Capuchin Monkeys.Frontiers in veterinary science · 2022Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population.International journal for parasitology. Parasites and wildlife · 2020Article
- Urinary suPAR: a non-invasive biomarker of infection and tissue inflammation for use in studies of large free-ranging mammals.Royal Society open science · 2020Article
- Urinary Cortisol Increases During a Respiratory Outbreak in Wild Chimpanzees.Frontiers in veterinary science · 2020Article
- Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees.PloS one · 2020Article
- Urinary neopterin levels increase and predict survival during a respiratory outbreak in wild chimpanzees (Taï National Park, Côte d'Ivoire).Scientific reports · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Monitoring immune system activation of wild animals has garnered increasing interest within the field of ecological immunology, leading to an urgent need for non-invasive biomarkers measuring these changes. Urinary neopterin, a marker of the cell-mediated immune response, is validated as an immune-related biomarker in captive and laboratory animals. However, wild animals naturally host higher and chronic pathogen loads. Therefore, detection and quantification of additional infections via neopterin might not be possible against the background of a chronically challenged immune system. To assess the suitability of urinary neopterin in wild animals, we measured neopterin corrected for specific gravity with an enzyme immunoassay in 185 samples collected before, during and after a respiratory disease outbreak in 28 individuals from a group of wild chimpanzees (Taï National Park, Côte d'Ivoire). Urinary neopterin levels were significantly higher during periods when individuals showed respiratory symptoms versus before and after the outbreak. Furthermore, urinary neopterin levels were significantly higher in individuals that died, with higher levels already apparent before the outbreak, suggesting individuals may have an already activated immune system. Measuring urinary neopterin levels, with other biomarkers of energetic condition, stress challenges, and reproduction will contribute towards a deeper understanding of life-history trade-offs in wild animals.
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