ArticleScientific reports2018
The Impact of Blood Transfusion on Recurrence and Mortality Following Colorectal Cancer Resection: A Propensity Score Analysis of 4,030 Patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Enhanced Functional and Surgical Outcomes With 3D Printing in Orthopedic Oncology: A Comparative Meta-Analysis Against Conventional Techniques.Journal of surgical oncology · 2025Pooled it
- Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review.Cancer immunology, immunotherapy : CII · 2025Pooled it
- Pooled it
- Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis.General thoracic and cardiovascular surgery · 2023Pooled it
- Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis.Surgery today · 2021Pooled it
- [Safety of cell salvage in tumor surgery : Systematic review with meta-analysis].Der Anaesthesist · 2020Pooled it
- Trial
- Preoperative anemia, transfusions and survival in colorectal cancer surgery-A retrospective study.Wiener klinische Wochenschrift · 2026Article
- Single Cancer Center Experience on Patient Blood Management Eligibility in Oncological Surgery.Journal of clinical medicine · 2026Article
- Influence of blood transfusion on outcomes in patients with gastric cancer.World journal of gastroenterology · 2026Article
- Evaluation of alternative transfusion triggers in hemodynamically stable, non-ventilated cancer patients: a prospective observational study.Scientific reports · 2025Observational
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Oncologic Outcomes of Intraoperative Autologous Blood Transfusion for Major Oncologic Resection.Annals of surgical oncology · 2025Article
- Association of stress hyperglycemia ratio with hospital mortality and acute kidney injury in patients with transfusion.Clinical and experimental nephrology · 2025Article
- Article
- Robotic versus laparoscopic anterior resection: comparative short-term outcomes in a propensity score matched cohort.Journal of robotic surgery · 2025Article
- Golden vision: The potential of yellow enhancement in laparoscopic abdominal surgeries and surgical education.World journal of gastrointestinal endoscopy · 2025Review
- The Effect of Preoperative Anemia on Blood Transfusion Outcomes in Major Head and Neck Cancer Surgery.Cancers · 2025Article
- Establishing high risk factors for recurrence in stage I/II colorectal cancer: a metropolitan perspective.World journal of surgical oncology · 2025Article
- Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Whether blood transfusion exacerbates cancer outcomes after surgery in humans remains inconclusive. We utilized a large cohort to investigate the effect of perioperative blood transfusion on cancer prognosis following colorectal cancer (CRC) resection. Patients with stage I through III CRC undergoing tumour resection at a tertiary medical center between 2005 and 2014 were identified and evaluated through August 2016. Propensity score matching was used to cancel out imbalances in patient characteristics. Postoperative disease-free survival (DFS) and overall survival (OS) were analysed using Cox regression model. A total of 4,030 and 972 patients were analysed before and after propensity score matching. Cox regression analyses demonstrated blood transfusion associated with shorter DFS and OS before and after matching (hazard ratio: 1.41, 95% CI: 1.2-1.66 for DFS; 1.97, 95% CI: 1.6-2.43 for OS). Larger transfusion volume was linked to higher overall mortality (≤4 units vs. nil, HR = 1.58; >4 units vs. nil, HR = 2.32) but not more cancer recurrence. Preoperative anemia was not associated with decreased survival after adjusting covariates. Perioperative blood transfusion was associated with worse cancer prognosis after curative colorectal resection, independently of anemia status. Strategies aimed at minimizing transfusion requirements should be further developed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.