ArticleScientific reports2018
Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Epidemiological trends and determinants of mumps outbreaks: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment.International journal of environmental research and public health · 2020Pooled it
- A Chimeric Virus Approach Reveals the Matrix (M) Gene as a Critical Modulator of Mumps Virus Neurovirulence.Vaccines · 2026Article
- Lineage Diversification and Evolutionary Dynamics of theMicroorganisms · 2026Article
- Age- and Sex-Dependent Heterogeneity in Mumps Virus Immunity Among US Blood Donors Born Between 1928-1993.The Journal of infectious diseases · 2026Article
- Development of a Novel mRNA Vaccine AgainstBioinformatics and biology insights · 2025Article
- Alveolar macrophages are early targets of mumps virus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Serologic Cross-Reactivity between the Mumps Virus Vaccine Genotype A Strain and the Circulating Genotype G Strain.Viruses · 2024Article
- Investigating Local Patterns of Mumps Virus Circulation, Using a Combination of Molecular Tools.Viruses · 2023Article
- Disentangling the causes of mumps reemergence in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Improved Immunogenicity of the Inactivated F Genotype Mumps Vaccine against Diverse Circulating Mumps Viruses in Mice.Vaccines · 2023Article
- Exploring the Mumps Virus Glycoproteins: A Review.Viruses · 2022Review
- Streamlined Whole-Genome Sequencing of Mumps Virus for High-Resolution Outbreak Analysis.Journal of clinical microbiology · 2022Article
- Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017.Frontiers in microbiology · 2022Article
- Mumps outbreak among fully vaccinated school-age children and young adults, Portugal 2019/2020.Epidemiology and infection · 2021Article
- Characterization of Natural and Synthetic Sialoglycans Targeting the Hemagglutinin-Neuraminidase of Mumps Virus.Frontiers in chemistry · 2021Article
- Dynamical footprints enable detection of disease emergence.PLoS biology · 2020Article
- Mumps: an Update on Outbreaks, Vaccine Efficacy, and Genomic Diversity.Clinical microbiology reviews · 2020Review
- Detecting critical slowing down in high-dimensional epidemiological systems.PLoS computational biology · 2020Article
- Combining genomics and epidemiology to track mumps virus transmission in the United States.PLoS biology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The surface proteins of the mumps virus, the fusion protein (F) and haemagglutinin-neuraminidase (HN), are key factors in mumps pathogenesis and are important targets for the immune response during mumps virus infection. We compared the predicted amino acid sequences of the F and HN genes from Dutch mumps virus samples from the pre-vaccine era (1957-1982) with mumps virus genotype G strains (from 2004 onwards). Genotype G is the most frequently detected mumps genotype in recent outbreaks in vaccinated communities, especially in Western Europe, the USA and Japan. Amino acid differences between the Jeryl Lynn vaccine strains (genotype A) and genotype G strains were predominantly located in known B-cell epitopes and in N-linked glycosylation sites on the HN protein. There were eight variable amino acid positions specific to genotype A or genotype G sequences in five known B-cell epitopes of the HN protein. These differences may account for the reported antigenic differences between Jeryl Lynn and genotype G strains. We also found amino acid differences in and near sites on the HN protein that have been reported to play a role in mumps virus pathogenesis. These differences may contribute to the occurrence of genotype G outbreaks in vaccinated communities.
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