ArticleScientific reports2018
Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
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- Ultrasensitive detection and quantification of bovine Deltapapillomavirus in the semen of healthy horses.Scientific reports · 2025Article
- Bovine papillomavirus vertical transmission: BPV diversity and expression in maternal and fetal tissues.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Bovine Papillomavirus Type 1 Infection in an Equine Congenital Papilloma.Pathogens (Basel, Switzerland) · 2023Article
- Possible etiological association of ovine papillomaviruses with bladder tumors in cattle.Virus research · 2023Review
- Congenital cutaneous fibropapillomatosis without evidences of papillomavirus infection in a Holstein-Friesian calf.The Journal of veterinary medical science · 2021Article
- Evidence from a Series of 104 Equine Sarcoids Suggests That Most Sarcoids in New Zealand Are Caused by Bovine Papillomavirus Type 2, although Both BPV1 and BPV2 DNA Are Detectable in around 10% of Sarcoids.Animals : an open access journal from MDPI · 2021Article
- Detection and quantification of bovine papillomavirus DNA by digital droplet PCR in sheep blood.Scientific reports · 2021Article
- Environmental DNA monitoring of oncogenic viral shedding and genomic profiling of sea turtle fibropapillomatosis reveals unusual viral dynamics.Communications biology · 2021Article
- Congenital Oral Squamous Cell Carcinoma in a Suckling Piglet.Case reports in veterinary medicine · 2021Article
- Association Between BoLA-DRB3.2 Polymorphism and Bovine Papillomavirus Infection for Bladder Tumor Risk in Podolica Cattle.Frontiers in veterinary science · 2021Article
- Novel Production of Bovine Papillomavirus Pseudovirions in Tobacco Plants.Pathogens (Basel, Switzerland) · 2020Article
- High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil.Pathogens (Basel, Switzerland) · 2020Article
- Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily.Pathogens (Basel, Switzerland) · 2020Article
- Bovine Papillomavirus Type 2 Infection Associated with Papillomatosis of the Amniotic Membrane in Water Buffaloes (Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital fibropapillomatosis of the gingiva and oral mucosa and epidermal hyperplasia of the lip are described, for the first time, in two newborn lambs. Expression of the E5 oncoprotein of bovine deltapapillomavirus types 2 (BPV-2) and -13 (BPV-13) was detected in both fibropapillomas and the hyperplastic epidermal cells suggesting the BPV infection was the cause of the proliferative lesions. No DNA sequences of BPV-1 and BPV-14 were detected. Both BPV-2 and BPV-13 DNA were also amplified from peripheral blood mononuclear cells (PBMCs) of the newborn lambs' dams. The concordance between BPV genotypes detected in the blood of dam and the oral and skin pathological samples of their offspring suggests that a vertical hematogeneous transmission was most likely source of BPV infection. Immunoblotting revealed the presence of E5 dimers allowing the viral protein to be biologically active. E5 dimers bind and activate the platelet derived growth factor β receptor (PDGFβR), a major molecular mechanism contributing to disease. The detection of E5 protein within the proliferating cells therefore adds further evidence that the BPV infection was the cause of the proliferative lesions seen in these lambs. This is the first evidence of vertical transmission of BPVs in sheep resulting in a clinical disease.
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