Evidence map›Paper›PMID 30190412›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.

Veronica T Cheli, Diara A Santiago González, Leandro N Marziali, Norma N Zamora, María E Guitart, Vilma Spreuer, Juana M Pasquini, Pablo M Paez

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 62 citations in OpenAlex.

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  13. Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Veronica T CheliHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Diara A Santiago GonzálezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.ORCID 0000-0001-8413-4046
Leandro N MarzialiHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Norma N ZamoraHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
María E GuitartDepartment of Biological Chemistry, Biological and Physical Chemistry Institute (IQUIFIB-CONICET). School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina 1113.ORCID 0000-0002-5511-7148
Vilma SpreuerHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Juana M PasquiniDepartment of Biological Chemistry, Biological and Physical Chemistry Institute (IQUIFIB-CONICET). School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina 1113.
Pablo M PaezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and ppaez@buffalo.edu.ORCID 0000-0001-9362-9454
New York University · USConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Enabling Access to Cutting-Edge Biomedical and Behavioral ScienceR25GM095459 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2012 to 2021
$4.4M
NIGMS NIH HHS R25 GM095459
6 · The paper itself

Abstract

The divalent metal transporter 1 (DMT1) is a multimetal transporter with a primary role in iron transport. Although DMT1 has been described previously in the CNS, nothing was known about the role of this metal transporter in oligodendrocyte maturation and myelination. To determine whether DMT1 is required for oligodendrocyte progenitor cell (OPC) maturation, we used siRNAs and the

Indexed as

AnimalsCation Transport ProteinsCells, CulturedCerebral CortexFemaleIronMaleMiceMice, KnockoutMice, TransgenicOligodendrocyte Precursor CellsRandom AllocationSolute Carrier Family 11, Member 2Cation Transport ProteinsIronSolute Carrier Family 11, Member 2DMT1iron uptakemyelinationoligodendrocyteremyelination

Identifiers

PMID30190412
PMCPMC6199407
OpenAlexW2891678466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.