Evidence map›Paper›PMID 30190342›Full record

ArticleHaematologica2019

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.

Anna Lucia Fedullo, Monica Messina, Loredana Elia, Alfonso Piciocchi, Valentina Gianfelici, Alessia Lauretti, Stefano Soddu, Maria Cristina Puzzolo, Clara Minotti, Felicetto Ferrara and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  8. How I treat Ph+ acute lymphoblastic leukemia.Future oncology (London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Anna Lucia FedulloHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Monica MessinaHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Loredana EliaHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Alfonso PiciocchiGIMEMA Data Center, Rome.
Valentina GianfeliciHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Alessia LaurettiHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Stefano SodduGIMEMA Data Center, Rome.
Maria Cristina PuzzoloHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Clara MinottiHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Felicetto FerraraDivision of Hematology and Stem Cell Transplantation Unit, Cardarelli Hospital, Naples.
Bruno MartinoHematology Unit, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria.
Patrizia ChiusoloInstitute of Hematology, Catholic University, Rome.
Valeria CalafioreDivision of Hematology, AOU Policlinico, University of Catania.
Stefania Paolini"L. and A. Seràgnoli" Institute of Hematology, University of Bologna.
Marco VignettiHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Antonella VitaleHematology, Department of Translational and Precision Medicine, Sapienza University, Rome.
Anna GuariniDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Robin FoàHematology, Department of Translational and Precision Medicine, Sapienza University, Rome chiaretti@bce.uniroma1.it rfoa@bce.uniroma1.it.
Sabina ChiarettiHematology, Department of Translational and Precision Medicine, Sapienza University, Rome chiaretti@bce.uniroma1.it rfoa@bce.uniroma1.it.
Sapienza University of Rome · ITFondazione Gimema Onlus · ITAzienda ospedaliera "Bianchi-Melacrino-Morelli" · ITCatholic University of America · USFatebenefratelli Hospital · ITUniversity of Bologna · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116 newly diagnosed adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia enrolled in four different GIMEMA protocols, all based on a chemotherapy-free induction strategy. This analysis showed that patients with Philadelphia chromosome-positive acute lymphoblastic leukemia carry an average of 7.8 lesions/case, with deletions outnumbering gains (88%

Indexed as

Genetic Predisposition to DiseaseGenetic VariationGenomicsAdolescentAdultAgedAged, 80 and overDNA Copy Number VariationsFemaleGenetic Association StudiesHumansMaleMiddle AgedMutationPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosis

Identifiers

PMID30190342
PMCPMC6355475
OpenAlexW2892257538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.