Evidence map›Paper›PMID 30190339›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.

Jason A Justice, Daniel T Manjooran, Chung-Yang Yeh, Karen A Hartnett-Scott, Anthony J Schulien, Gabrielle J Kosobucki, Shalom Mammen, Michael J Palladino, Elias Aizenman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jason A JusticeDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Daniel T ManjooranDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Chung-Yang YehDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Karen A Hartnett-ScottDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Anthony J SchulienDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Gabrielle J KosobuckiDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shalom MammenDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Michael J PalladinoDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Elias AizenmanDepartments of Neurobiology (J.A.J., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., E.A.) and Pharmacology and Chemical Biology (D.T.M., M.J.P.) and Pittsburgh Institute for Neurodegenerative Diseases (J.A.J., D.T.M., C.-Y.Y., K.A.H.-S., A.J.S., G.J.K., S.M., M.J.P., E.A.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania redox@pitt.edu.
University of Pittsburgh · US

Funding

Liberation of Intracellular Zinc and Neuronal Cell DeathR01NS043277 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENMAN, ELIAS · 2002 to 2022
$8.2M
NINDS NIH HHS R01 NS043277
6 · The paper itself

Abstract

We present the design of an innovative molecular neuroprotective strategy and provide proof-of-concept for its implementation, relying on the injury-mediated activation of an ectopic gene construct. As oxidative injury leads to the intracellular liberation of zinc, we hypothesize that tapping onto the zinc-activated metal regulatory element (

Indexed as

AnimalsCell DeathCells, CulturedCell SurvivalCerebral CortexFemaleHepacivirusHepatitis CMaleNeuronsNeuroprotectionPotassiumProtein TransportRatsRNA-Dependent RNA PolymeraseShab Potassium ChannelsKcnb1 protein, ratNS-5 protein, hepatitis C virusPotassiumRNA-Dependent RNA PolymeraseShab Potassium ChannelsViral Nonstructural ProteinsZinc

Identifiers

PMID30190339
PMCPMC6193254
OpenAlexW2890486696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.