Evidence map›Paper›PMID 30190328›Full record

ReviewBiochemical Society transactions2018

Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria?

Lauren K Wareham, Hannah M Southam, Robert K Poole

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemical Society transactions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Bioenergetics and Reactive Nitrogen Species in Bacteria.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Review
  16. Biome-specific distribution of Ni-containing carbon monoxide dehydrogenases.Extremophiles : life under extreme conditions · 2022
    Article
  17. Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics.International journal of molecular sciences · 2021
    Review
  18. Antioxidants (Basel, Switzerland) · 2021
    Article
  19. Early administration of L-arginine inFASEB bioAdvances · 2021
    Article
  20. Antimicrobial nanomedicine for ocular bacterial and fungal infection.Drug delivery and translational research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lauren K WarehamVanderbilt University Medical Center, Vanderbilt Eye Institute, 11420 Medical Research Building IV, 215B Garland Avenue, Nashville, TN 37232-0654, U.S.A.
Hannah M SouthamDepartment of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K.
Robert K PooleDepartment of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K. r.poole@sheffield.ac.uk.
University of Sheffield · GBVanderbilt University Medical Center · US

Funding

Biotechnology and Biological Sciences Research Council BB/M022579/1
6 · The paper itself

Abstract

A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H

Indexed as

BacteriaBacterial Physiological PhenomenaCarbon MonoxideGasotransmittersHydrogen SulfideModels, BiologicalMycobacterium tuberculosisNitric OxideSignal TransductionCarbon MonoxideGasotransmittersHydrogen SulfideNitric Oxidecarbon monoxidecellular signallinggasotransmittershydrogen sulfidenitric oxide

Identifiers

PMID30190328
PMCPMC6195638
OpenAlexW2892058070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.