Evidence map›Paper›PMID 30190287›Full record

ArticleThe Journal of experimental medicine2018

Sox12 promotes T reg differentiation in the periphery during colitis.

Shigeru Tanaka, Akira Suto, Taro Iwamoto, Takahiro Kageyama, Tomohiro Tamachi, Hiroaki Takatori, Kotaro Suzuki, Koichi Hirose, Osamu Ohara, Véronique Lefebvre and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. SOX on tumors, a comfort or a constraint?Cell death discovery · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shigeru TanakaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.ORCID 0000-0002-8466-110X
Akira SutoDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan suaki@faculty.chiba-u.jp.ORCID 0000-0002-2593-565X
Taro IwamotoDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.
Takahiro KageyamaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.
Tomohiro TamachiDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.
Hiroaki TakatoriDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.
Kotaro SuzukiDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.
Koichi HiroseDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan.ORCID 0000-0001-7498-9630
Osamu OharaDepartment of Technology Development, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan.ORCID 0000-0002-3328-9571
Véronique LefebvreDepartment of Surgery/Division of Orthopedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Hiroshi NakajimaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan nakajimh@faculty.chiba-u.jp.ORCID 0000-0001-8595-9381
Chiba University · JPChildren's Hospital of Philadelphia · USKazusa DNA Research Institute · JP

Funding

Roles of SOXC proteins in osteogenic cellsR01AR068308 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI LEFEBVRE, VERONIQUE M · 2016 to 2020
$2.4M
NIAMS NIH HHS R01 AR068308
6 · The paper itself

Abstract

Peripherally induced regulatory T (pT reg) cells play indispensable roles in regulating gut inflammation; however, the mechanism underling the differentiation of pT reg cells under inflammatory conditions remains largely unknown. Here, we show that the expression of Sox12, a member of SoxC family, is significantly induced in T reg cells in colitic mice. We also show that TCR-NFAT signaling induces Sox12 expression in CD4

Indexed as

AnimalsCell DifferentiationColitisDisease Models, AnimalForkhead Transcription FactorsMiceMice, Inbred BALB CMice, KnockoutSignal TransductionSOXC Transcription FactorsT-Lymphocytes, RegulatoryTransforming Growth Factor betaForkhead Transcription FactorsFoxp3 protein, mouseSox12 protein, mouseSOXC Transcription FactorsTransforming Growth Factor beta

Identifiers

PMID30190287
PMCPMC6170178
OpenAlexW2891645375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.