ArticleEBioMedicine2018
Hepatitis E virus infection in acute non-traumatic neuropathy: A large prospective case-control study in China.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Extra-Hepatic Manifestations of Hepatitis E Virus (HEV): A Narrative Review on Meningoencephalitis.Life (Basel, Switzerland) · 2026Review
- Hepatitis E virus-associated neurological injury and neurotropic cellular mechanisms.Frontiers in cellular and infection microbiology · 2026Review
- From discovery to treatment: tracing the path of hepatitis E virus.Virology journal · 2024Review
- Neurological manifestation of HEV infection: still a rare disease entity?Journal of neurology · 2024Article
- Whole genome sequencing reveals insights into hepatitis E virus genome diversity, and virus compartmentalization in chronic hepatitis E.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2023Article
- [Intrahepatic and extrahepatic clinical manifestations and treatment progress for hepatitis type E].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood-brain barrier, and invades the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Estimating the global prevalence of hepatitis E virus in swine and pork products.One health (Amsterdam, Netherlands) · 2022Article
- Hepatitis E Virus Infection: Neurological Manifestations and Pathophysiology.Pathogens (Basel, Switzerland) · 2021Review
- Review
- Neurological manifestations of hepatitis E virus infection: An overview.World journal of gastroenterology · 2021Review
- Towards the Improved Accuracy of Hepatitis E Diagnosis in Vulnerable and Target Groups: A Global Perspective on the Current State of Knowledge and the Implications for Practice.Healthcare (Basel, Switzerland) · 2021Review
- Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology.Open forum infectious diseases · 2020Article
- A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection.Medical sciences (Basel, Switzerland) · 2020Review
- Extrahepatic manifestations of hepatitis E virus: An overview.Clinical and molecular hepatology · 2020Review
- Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case-control study in China.Emerging microbes & infections · 2020Article
- Review
- The Clinical Perspective on Hepatitis E.Viruses · 2019Review
- Review
- Extrahepatic manifestations and HEV, the genotype matters.EBioMedicine · 2018Article
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Neurological manifestations are potentially associated with hepatitis E virus (HEV) infection in Europe, mainly attributed to genotype (GT) 3 HEV infection. In this study, we determined the frequency and causal relationship of HEV in patients with non-traumatic neurological disorders in China, where GT4 HEV is prevalent. 1117 consecutive patients diagnosed with neurological illnesses in a hospital of eastern China and 1475 healthy controls who took routine examination in the same hospital were tested for HEV by serology and molecular methods. Anti-HEV IgM antibodies were detectable in 6 (0.54%) of the patients and 10 (0.68%) of the healthy controls (P = 0.651). Serum HEV RNA was detected in all of the 16 individuals with positive anti-HEV IgM. The six patients with HEV infection included two viral encephalitis, two posterior circulation ischemia, one peripheral neuropathy and one Guillian-Barré syndrome. They had no symptoms of acute viral hepatitis except two patients of viral encephalitis that showed mildly transaminitis. Additional, 39.51% patients and 35.63% controls without acute HEV infection were positive for anti-HEV IgG (P = 0.144). Anti-HEV IgG positivity was more frequent in male and elderly in both the patients and control groups, but unrelated to the incidence of any non-traumatic neurological illness, hospital stay or treatment outcome, except linking to better outcome of hemorrhagic stroke disease. These data demonstrated that HEV appears not to contribute to acute neurological disorders in China. Nevertheless, we cannot exclude a possible causative role, suggesting that testing HEV in this population, especially in situations of unexplained deregulated liver function would be warranted.
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