Evidence map›Paper›PMID 30190180›Full record

ArticlePediatric neurology2018

Hammersmith Infant Neurological Examination Asymmetry Score Distinguishes Hemiplegic Cerebral Palsy From Typical Development.

Krystal Hay, MaryAnn Nelin, Helen Carey, Olena Chorna, Melissa Moore-Clingenpeel Ma Mas, Nathalie Maitre, NCH Early Developmental Group

Open access · greenAbstract read
In one paragraph

Article in Pediatric neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Standardizing early cerebral palsy detection in high-risk infants: reducing age at diagnosis through a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Observational
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Social Determinants of Health in Cerebral Palsy.Journal of clinical medicine · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Krystal HayCenter for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital, Columbus, Ohio.
MaryAnn NelinCenter for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital, Columbus, Ohio.
Helen CareyCenter for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital, Columbus, Ohio.
Olena ChornaCenter for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital, Columbus, Ohio.
Melissa Moore-Clingenpeel Ma MasBiostatistics Core, Research Institute Nationwide Children's Hospital.
Nathalie MaitreCenter for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital, Columbus, Ohio; Department of Hearing and Speech Sciences, Vanderbilt Kennedy Center, Nashville, Tennessee. Electronic address: Nathalie.maitre@nationwidechildrens.org.
NCH Early Developmental Group
Nationwide Children's Hospital · US

Funding

Early Childhood Constraint Therapy for Sensory/Motor Impairment in Cerebral PalsyR01HD081120 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI MAITRE, NATHALIE · 2015 to 2025
$5.9M
NICHD NIH HHS R01 HD081120
6 · The paper itself

Abstract

backgroundThe Hammersmith Infant Neurological Examination is one of several useful tools for early identification of cerebral palsy; however, cut-off scores for cerebral palsy do not consistently distinguish infants with hemiplegia from those typically developing. We hypothesized that use of an asymmetry score, in addition to the assessment's standard total cutoff score, could remedy this problem in a clinical setting.

methodsThis retrospective study of a neonatal intensive care follow-up program with consistent clinical use of the Hammersmith Infant Neurological Examination matched infants with a diagnosis of cerebral palsy to infants without motor delays or evidence of neurodevelopmental impairments. Groups had same corrected and gestational ages at Hammersmith Infant Neurological Examination assessment. Asymmetry presence was recorded.

resultsOf 74 infants with cerebral palsy, 28 had quadriplegia, 11 had diplegia, and 35 had hemiplegia. Median total Hammersmith Infant Neurological Examination and asymmetry scores for hemiplegia were 57.5 and 10 versus 76 and 0 for those without cerebral palsy. Sensitivity and specificity to distinguish hemiplegia from typical development by combining a total Hammersmith Infant Neurological Examination score less than 63 and an asymmetry score greater than 5 were 91.8% and 100%, respectively.

conclusionsIn a clinical setting, combining total Hammersmith Infant Neurological Examination and asymmetry scores can help providers differentiate infants with hemiplegia from those typically developing.

Indexed as

Intensive Care Units, NeonatalCerebral PalsyChild DevelopmentFemaleFollow-Up StudiesHemiplegiaHumansInfantInfant, NewbornMaleNeurologic ExaminationQuadriplegiaRetrospective StudiesSensitivity and SpecificitySeverity of Illness IndexAsymmetryCerebral palsyHemiplegiaNeurological examination

Identifiers

PMID30190180
PMCPMC6320694
OpenAlexW2884203690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.