Evidence map›Paper›PMID 30190005›Full record

ArticleJournal of the American College of Cardiology2018

Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence.

Théo A Meister, Stefano F Rimoldi, Rodrigo Soria, Robert von Arx, Franz H Messerli, Claudio Sartori, Urs Scherrer, Emrush Rexhaj

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00837642 (Vascular Dysfunction in Offspring of Assisted Reproduction Technologies), which is not on this map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
30.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00837642 unknown statusnot on this map

Vascular Dysfunction in Offspring of Assisted Reproduction Technologies

TypeobservationalSponsorUniversity of Lausanne HospitalsRan2008 to 2021Enrolled100ConditionsInfertilityArmsTransthoracic echocardiography
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Transgenerational Impact of Environmental Change.Advances in experimental medicine and biology · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Théo A MeisterDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland.
Stefano F RimoldiDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland.
Rodrigo SoriaDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland.
Robert von ArxDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland.
Franz H MesserliDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland.
Claudio SartoriDepartment of Internal Medicine, University Hospital, Lausanne, Switzerland.
Urs ScherrerDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland; Faculty of Sciences, Department of Biology, University of Tarapacá, Arica, Chile.
Emrush RexhajDepartment of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland. Electronic address: emrush.rexhaj@insel.ch.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown.

objectivesThis study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group.

methodsFive years after the initial assessment, the study investigators reassessed vascular function and performed 24-h ambulatory blood pressure (BP) monitoring (ABPM) in 54 young, apparently healthy participants conceived through ART and 43 age- and sex-matched controls.

resultsPremature vascular aging persisted in ART-conceived subjects, as evidenced by a roughly 25% impairment of flow-mediated dilation of the brachial artery (p < 0.001) and increased pulse-wave velocity and carotid intima-media thickness. Most importantly, ABPM values (systolic BP, 119.8 ± 9.1 mm Hg vs. 115.7 ± 7.0 mm Hg, p = 0.03; diastolic BP, 71.4 ± 6.1 mm Hg vs. 69.1 ± 4.2 mm Hg, p = 0.02 ART vs. control) and BP variability were markedly higher in ART-conceived subjects than in control subjects. Eight of the 52 ART participants, but only 1 of the 43 control participants (p = 0.041 ART vs. controls) fulfilled ABPM criteria of arterial hypertension (>130/80 mm Hg and/or >95th percentile).

conclusionsART-induced premature vascular aging persists in apparently healthy adolescents and young adults without any other detectable classical cardiovascular risk factors and progresses to arterial hypertension. (Vascular Dysfunction in Offspring of Assisted Reproduction Technologies; NCT00837642.).

Indexed as

AdolescentBlood Pressure Monitoring, AmbulatoryBrachial ArteryCarotid ArteriesCarotid Intima-Media ThicknessCase-Control StudiesEndothelium, VascularFemaleFemoral ArteryHumansHypertensionMalePulse Wave AnalysisReproductive Techniques, AssistedSwitzerlandUltrasonographyarterial hypertensionassisted reproductive technologiesendothelial dysfunctionflow-mediated dilation

Identifiers

PMID30190005
OpenAlexW2889362606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.