Evidence map›Paper›PMID 30189652›Full record

ArticleJournal of clinical medicine2018

The Thomsen-Friedenreich Antigen: A Highly Sensitive and Specific Predictor of Microsatellite Instability in Gastric Cancer.

Stefan Mereiter, Karol Polom, Coralie Williams, Antonio Polonia, Mariana Guergova-Kuras, Niclas G Karlsson, Franco Roviello, Ana Magalhães, Celso A Reis

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. The emerging role of Fusobacteria in carcinogenesis.European journal of clinical investigation · 2024
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  6. The role ofActa pharmaceutica Sinica. B · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Stefan MereiterI3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-465 Porto, Portugal. smereiter@ipatimup.pt.
Karol PolomGeneral Surgery and Surgical Oncology Department, University of Siena, 53100 Siena, Italy. surgoncolclub@gmail.com.
Coralie WilliamsAriana Pharmaceuticals, 75016 Paris, France. c.williams@arianapharma.com.
Antonio PoloniaDepartment of Pathology, IPATIMUP Diagnostics, University of Porto, 4200-135 Porto, Portugal. apolonia@ipatimup.pt.ORCID 0000-0001-8312-1681
Mariana Guergova-KurasAriana Pharmaceuticals, 75016 Paris, France. mariana.kuras@free.fr.
Niclas G KarlssonMedical Biochemistry, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden. niclas.karlsson@medkem.gu.se.
Franco RovielloGeneral Surgery and Surgical Oncology Department, University of Siena, 53100 Siena, Italy. franco.roviello@gmail.com.ORCID 0000-0003-4122-1259
Ana MagalhãesI3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-465 Porto, Portugal. amagalhaes@ipatimup.pt.
Celso A ReisI3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-465 Porto, Portugal. celsor@ipatimup.pt.ORCID 0000-0002-0286-6639
Universidade do Porto · PTUniversity of Siena · ITUniversity of Gothenburg · SE

Funding

European Regional Development Fund NORTE-01-0145-FEDER-000029Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-007274Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-016585Fundação para a Ciência e a Tecnologia PTDC/BBB-EBI/0567/2014Fundação para a Ciência e a Tecnologia UID/BIM/04293/2013Seventh Framework Programme 316929
6 · The paper itself

Abstract

Microsatellite instability (MSI) is a distinct molecular subtype of gastric cancer. In recent years, the clinical consequences of MSI and the therapeutic opportunities to target this peculiar cancer subtype became evident. However, despite the importance of MSI for the stratification of patients, the time and resources required for diagnosis still present an obstacle. In an attempt to identify a new marker for MSI in gastric cancer, we evaluated the expression of five cancer-associated glycan epitopes in a cohort of 13 MSI and 17 microsatellite stable (MSS) cases. Our analysis revealed a highly significant (

Indexed as

cancer biomarkergastric cancerglycosylationmicrosatellite instabilitymucin type glycansO-glycan truncation

Identifiers

PMID30189652
PMCPMC6162870
OpenAlexW2891155928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.