Evidence map›Paper›PMID 30189644›Full record

ArticleMolecules (Basel, Switzerland)2018

Molecular Recognition of Parallel G-quadruplex [d-(TTGGGGT)]₄ Containing

Ritu Barthwal, Zia Tariq

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Genes · 2023
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ritu BarthwalDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India. ritubfbs@iitr.ac.in.
Zia TariqDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India. ziatariq88@gmail.com.
Indian Institute of Technology Roorkee · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anticancer drug daunomycin exerts its influence by multiple strategies of action to interfere with gene functioning. Besides inhibiting DNA/RNA synthesis and topoisomerase-II, it affects the functional pathway of telomere maintenance by the telomerase enzyme. We present evidence of the binding of daunomycin to parallel-stranded tetramolecular [d-(TTGGGGT)]₄ guanine (G)-quadruplex DNA comprising telomeric DNA from

Indexed as

G-QuadruplexesAntibiotics, AntineoplasticCalorimetry, Differential ScanningCircular DichroismDaunorubicinDNA, ProtozoanMagnetic Resonance SpectroscopyModels, MolecularMolecular ConformationMolecular StructureNucleic Acid DenaturationTelomereTetrahymenaAntibiotics, AntineoplasticDaunorubicinDNA, Protozoancircular dichroismdaunomycindifferential scanning calorimetryG-quadruplex DNAintermolecular NOEsnuclear magnetic resonancerestrained molecular dynamics simulationssurface plasmon resonancethermal stabilization

Identifiers

PMID30189644
PMCPMC6225185
OpenAlexW2889891942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.