Evidence map›Paper›PMID 30189620›Full record

ArticleCancers2018

Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer.

Hang-Kang Chen, Shu-Mei Zhang, Junn-Liang Chang, Hsin-Chien Chen, Yi-Chun Lin, Cheng-Ping Shih, Huey-Kang Sytwu, Mei-Cho Fang, Yuan-Yung Lin, Chao-Yin Kuo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Hang-Kang ChenGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan. hwalongchen@yahoo.com.tw.ORCID 0000-0002-5344-2019
Shu-Mei ZhangGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. m1482073@gmail.com.ORCID 0000-0002-7983-8492
Junn-Liang ChangDepartment of Pathology, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan. junn9liang@yahoo.com.tw.
Hsin-Chien ChenDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. acolufreia@yahoo.com.tw.ORCID 0000-0002-5498-5621
Yi-Chun LinGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan. lyc_1023@yahoo.com.tw.
Cheng-Ping ShihDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. zhengping_shi@yahoo.com.tw.
Huey-Kang SytwuGraduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan. sytwu@ndmctsgh.edu.tw.
Mei-Cho FangLaboratory Animal Center, National Defense Medical Center, Taipei 11490, Taiwan. misa@mail.ndmctsgh.edu.tw.
Yuan-Yung LinGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan. yking1109@gmail.com.
Chao-Yin KuoDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. chefsketchup@hotmail.com.
Ai-Ho LiaoGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. aiho@mail.ntust.edu.tw.
Yueng-Hsiang ChuDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. chuyuenghsiang@gmail.com.ORCID 0000-0002-2587-958X
Chih-Hung WangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan. chw@ms3.hinet.net.
Tri-Service General Hospital · TWNational Defense Medical Center · TWNational Taiwan University of Science and Technology · TWMing Chuan University · TW

Funding

Medical Affairs Bureau Ministry of National Defense MAB-107-001Medical Affairs Bureau Ministry of National Defense MAB107-002Ministry of Science and Technology, Taiwan MOST103-2314-B-016-003Ministry of Science and Technology, Taiwan MOST104-2314-B-016-032-MY3Ministry of Science and Technology, Taiwan MOST106-2221-E-011-043-MY3National Taiwan University of Science and Technology NTUST-TSGH-107-02Teh-Tzer Study Group for Human Medical Research Foundation A1071025Teh-Tzer Study Group for HumanMedical Research Foundation A1041001Tri-Service General Hospital TSGH-C104-043Tri-Service General Hospital TSGH-C107-009
6 · The paper itself

Abstract

The use of cisplatin (CDDP), the most common chemotherapy drug for head and neck cancer, is limited by its undesirable side effects, especially nephrotoxicity. We investigated ultrasound microbubbles (USMB) as a tool to increase the local intra-tumoral CDDP level while decreasing systemic CDDP cytotoxicity. We allowed CDDP to interact with human serum albumin and then sonicated the resulting CDDP‒albumin complex to generate CDDP-loaded MBs (CDDP-MBs). We then established a head-and-neck tumor-bearing mouse model by implanting FaDu-fLuc/GFP cells into severe combined immunodeficiency mice and used IVIS

Indexed as

chemotherapycisplatinhead and neck cancermicrobubblenephrotoxicityultrasound

Identifiers

PMID30189620
PMCPMC6162676
OpenAlexW2889934102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.