Evidence map›Paper›PMID 30189611›Full record

ArticleNutrients2018

Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients.

Sara Nejatinamini, Brock J Debenham, Robin D Clugston, Asifa Mawani, Matthew Parliament, Wendy V Wismer, Vera C Mazurak

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  13. Article
  14. Review
  15. The Concept of Folic Acid in Health and Disease.Molecules (Basel, Switzerland) · 2021
    Review
  16. Article
  17. The role of vitamin D in head and neck cancer.Laryngoscope investigative otolaryngology · 2020
    Review
  18. Body composition changes in patients with head and neck cancer under active treatment: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sara NejatinaminiDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada. nejatina@ualberta.ca.ORCID 0000-0003-0309-1238
Brock J DebenhamDepartment of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada. Brock.Debenham@albertahealthservices.ca.
Robin D ClugstonDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada. clugston@ualberta.ca.ORCID 0000-0003-0264-9594
Asifa MawaniDepartment of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada. Asifa.Mawani@albertahealthservices.ca.
Matthew ParliamentDepartment of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada. Matthew.Parliament@albertahealthservices.ca.
Wendy V WismerDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada. wwismer@ualberta.ca.ORCID 0000-0002-8325-9338
Vera C MazurakDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada. vmazurak@ualberta.ca.
University of Alberta · CA

Funding

Canadian Institutes of Health Research 259704
6 · The paper itself

Abstract

Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body composition, inflammation and mucositis. In this prospective cohort study, dietary intakes (3-day food record), plasma levels of vitamins and C-reactive protein (CRP) were assessed at baseline (at diagnosis) and post-treatment (after 6⁻8 weeks of radiation therapy with or without chemotherapy). Computed tomography images were used to quantify body composition. Mucositis information was collected from health records of patients. Twenty-eight HNC patients (age 60 ± 10 years) completed both study time points. Patients who developed mucositis had significantly lower dietary intake of vitamins and plasma 25-hydroxy vitamin D (25-OHD) and

Indexed as

Adipose TissueAgedC-Reactive ProteinDietFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMucositisMuscle, SkeletalMuscular AtrophyProspective StudiesVitamin AVitamin A DeficiencyVitamin D25-hydroxyvitamin DC-Reactive ProteinVitamin AVitamin DVitaminsbody compositioncancer treatmenthead and neck cancermucositisskeletal muscle massvitamin status

Identifiers

PMID30189611
PMCPMC6165496
OpenAlexW2891178807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.