Evidence map›Paper›PMID 30189184›Full record

ArticleNeuropharmacology2018

Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein.

Nicolas B Senese, Max Oginsky, Richard R Neubig, Carrie Ferrario, Emily M Jutkiewicz, John R Traynor

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Targeting the 5-HTCell & bioscience · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicolas B SeneseDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Max OginskyDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Richard R NeubigDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48823, USA.
Carrie FerrarioDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Emily M JutkiewiczDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48109, USA.
John R TraynorDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: jtraynor@umich.edu.
University of Michigan–Ann Arbor · USMichigan State University · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Regulator of G protein signaling proteins differentially control opioid analgesiaR01DA035316 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2014 to 2018
$2.7M
Analysis of Motor Protein FunctionR01GM077067 · NIGMS · WASHINGTON STATE UNIVERSITY · PI PATE, EDWARD F · 2006 to 2009
$1.1M
NIDA NIH HHS R01 DA035316NIDA NIH HHS T32 DA007268NIGMS NIH HHS R01 GM077067NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

A single base mutation in the Gα

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsCA1 Region, HippocampalFemaleGene Knock-In TechniquesGTP-Binding Protein alpha Subunit, Gi2HippocampusImmobility Response, TonicMaleMiceMicroinjectionsPhenotypePiperazinesPyramidal CellsPyridinesReceptor, Serotonin, 5-HT1A8-Hydroxy-2-(di-n-propylamino)tetralinGTP-Binding Protein alpha Subunit, Gi2N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1ARGS ProteinsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsAntidepressant-like activityG proteinsHippocampusRGS proteinsSerotonin receptor

Identifiers

PMID30189184
PMCPMC6392198
OpenAlexW2890390423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.