Evidence map›Paper›PMID 30189149›Full record

ArticleJournal of dental research2019

Biological and Mechanical Evaluation of Novel Prototype Dental Composites.

H L Van der Laan, S L Zajdowicz, K Kuroda, B J Bielajew, T A Davidson, J Gardinier, D H Kohn, S Chahal, S Chang, J Liu and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Developments in resin-based composites.British dental journal · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

H L Van der Laan1 Macromolecular Science and Engineering, College of Engineering, University of Michigan, Ann Arbor MI, USA.
S L Zajdowicz2 Department of Biology, Metropolitan State University of Denver, Denver, CO, USA.
K Kuroda1 Macromolecular Science and Engineering, College of Engineering, University of Michigan, Ann Arbor MI, USA.
B J Bielajew3 Department of Biologic and Materials Sciences, Dental School, University of Michigan, Ann Arbor, MI, USA.
T A Davidson3 Department of Biologic and Materials Sciences, Dental School, University of Michigan, Ann Arbor, MI, USA.
J Gardinier3 Department of Biologic and Materials Sciences, Dental School, University of Michigan, Ann Arbor, MI, USA.
D H Kohn3 Department of Biologic and Materials Sciences, Dental School, University of Michigan, Ann Arbor, MI, USA.
S Chahal4 Department of Cariology, Restorative Sciences and Endodontics, Dental School, University of Michigan, Ann Arbor, MI, USA.
S Chang4 Department of Cariology, Restorative Sciences and Endodontics, Dental School, University of Michigan, Ann Arbor, MI, USA.
J Liu4 Department of Cariology, Restorative Sciences and Endodontics, Dental School, University of Michigan, Ann Arbor, MI, USA.
J Gerszberg5 Department of Chemical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA.
T F Scott1 Macromolecular Science and Engineering, College of Engineering, University of Michigan, Ann Arbor MI, USA.
B H Clarkson4 Department of Cariology, Restorative Sciences and Endodontics, Dental School, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMetropolitan State University of Denver · US

Funding

The design, development and evaluation of a nano/micro filled novel "smart" dentaU01DE023771 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLARKSON, BRIAN H, SCOTT, TIMOTHY FRANCIS · 2013 to 2017
$2.6M
NIDCR NIH HHS U01 DE023771
6 · The paper itself

Abstract

The breakdown of the polymeric component of contemporary composite dental restorative materials compromises their longevity, while leachable compounds from these materials have cellular consequences. Thus, a new generation of composite materials needed to be designed to have a longer service life and ensure that any leachable compounds are not harmful to appropriate cell lines. To accomplish this, we have developed concurrent thiol-ene-based polymerization and allyl sulfide-based addition-fragmentation chain transfer chemistries to afford cross-linked polymeric resins that demonstrate low shrinkage and low shrinkage stress. In the past, the filler used in dental composites mainly consisted of glass, which is biologically inert. In several of our prototype composites, we introduced fluorapatite (FA) crystals, which resemble enamel crystals and are bioactive. These novel prototype composites were benchmarked against similarly filled methacrylate-based bisphenol A diglycidyl ether dimethacrylate / triethylene glycol dimethacrylate (bisGMA/TEGDMA) composite for their cytotoxicity, mechanical properties, biofilm formation, and fluoride release. The leachables at pH 7 from all the composites were nontoxic to dental pulp stem cells. There was a trend toward an increase in total toughness of the glass-only-filled prototype composites as compared with the similarly filled bisGMA/TEGDMA composite. Other mechanical properties of the glass-only-filled prototype composites were comparable to the similarly filled bisGMA/TEGDMA composite. Incorporation of the FA reduced the mechanical properties of the prototype and bisGMA/TEGDMA composite. Biofilm mass and colony-forming units per milliliter were reduced on the glass-only-filled prototype composites as compared with the glass-only-filled bisGMA/TEGDMA composite and were significantly reduced by the addition of FA to all composites. Fluoride release at pH 7 was greatest after 24 h for the bisGMA/TEGDMA glass + FA composite as compared with the similarly filled prototypes, but overall the F

Indexed as

Composite ResinsDental MaterialsPolymethacrylic AcidsStress, MechanicalBisphenol A-Glycidyl MethacrylateHumansMaterials TestingMethacrylatesPolyethylene GlycolsPolymerizationBisphenol A-Glycidyl MethacrylateComposite ResinsDental MaterialsMethacrylatesPolyethylene GlycolsPolymethacrylic Acidsapatitesbiocompatibilitybiofilm(s)composite materialsfluoride(s)resin(s)

Identifiers

PMID30189149
PMCPMC6304716
OpenAlexW2890274137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.