ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2018
De novo transcriptome sequencing and metabolite profiling analyses reveal the complex metabolic genes involved in the terpenoid biosynthesis in Blue Anise Sage (Salvia guaranitica L.).
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 66 citations in OpenAlex.
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- Physiological and transcriptomic evaluation of salt tolerance in Egyptian tomato landraces at the seedling stage.BMC plant biology · 2025Article
- Water stress modulates terpene biosynthesis and morphophysiology at different ploidal levels in Lippia alba (Mill.) N. E. Brown (Verbenaceae).Protoplasma · 2024Article
- Illumina-based transcriptomic analysis of the fast-growing leguminous treeFrontiers in plant science · 2024Article
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- Changes in Metabolite Profiling and Expression Levels of Key Genes Involved in the Terpenoid Biosynthesis Pathway in Garden Sage (Metabolites · 2023Article
- Combined analysis of transcriptomics and metabolomics revealed complex metabolic genes for diterpenoids biosynthesis in different organs ofChinese herbal medicines · 2023Article
- Deciphering aroma formation during flowering in nectar tree (Forestry research · 2023Article
- The Molecular Network behind Volatile Aroma Formation in Pear (Life (Basel, Switzerland) · 2022Article
- Constitutive overexpression of GsIMaT2 gene from wild soybean enhances rhizobia interaction and increase nodulation in soybean (Glycine max).BMC plant biology · 2022Article
- New Insights into Methyl Jasmonate Regulation of Triterpenoid Biosynthesis in Medicinal Fungal SpeciesJournal of fungi (Basel, Switzerland) · 2022Article
- Overexpression of Terpenoid Biosynthesis Genes Modifies Root Growth and Nodulation in Soybean (Cells · 2022Article
- Transcriptome Analyses Revealed the Key Metabolic Genes and Transcription Factors Involved in Terpenoid Biosynthesis in Sacred Lotus.Molecules (Basel, Switzerland) · 2022Article
- Metabolome and Transcriptome Profiling Reveal That Four Terpenoid Hormones Dominate the Growth and Development of Sanghuangporus baumiiJournal of fungi (Basel, Switzerland) · 2022Article
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8 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Many terpenoid compounds have been extracted from different tissues of Salvia guaranitica. However, the molecular genetic basis of terpene biosynthesis pathways is virtually unknown. In this study, approximately 4 Gb of raw data were generated from the transcriptome of S. guaranitica leaves using Illumina HiSeq 2000 sequencing. After filtering and removing the adapter sequences from the raw data, the number of reads reached 32 million, comprising 186 million of high-quality nucleotide bases. A total of 61,400 unigenes were assembled de novo and annotated for establishing a valid database for studying terpenoid biosynthesis. We identified 267 unigenes that are putatively involved in terpenoid metabolism (including, 198 mevalonate and methyl-erythritol phosphate (MEP) pathways, terpenoid backbone biosynthesis genes and 69 terpene synthases genes). Moreover, three terpene synthase genes were studied for their functions in terpenoid biosynthesis by using transgenic Arabidopsis; most transgenic Arabidopsis plants expressing these terpene synthetic genes produced increased amounts of terpenoids compared with wild-type control. The combined data analyses from the transcriptome and metabolome provide new insights into our understanding of the complex metabolic genes in terpenoid-rich blue anise sage, and our study paves the way for the future metabolic engineering of the biosynthesis of useful terpene compounds in S. guaranitica.
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