ArticleAmerican journal of epidemiology2018
Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
177 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- CPNE1: A novel therapeutic target for myopia progression - from genetic GWAS discovery to functional validation in vitro and vivo.Journal of translational medicine · 2026Pooled it
- No genetic causality between appendectomy and gastrointestinal cancers: a Mendelian randomization study and meta-analysis in European population.Scientific reports · 2024Pooled it
- Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization.BMC medicine · 2023Pooled it
- Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation.The British journal of nutrition · 2023Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Pooled it
- Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Pooled it
- Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.BMC cancer · 2020Pooled it
- Article
- Applying Bayesian Multivariable Mendelian Randomisation to Prioritise Candidate Causal Traits From High-Dimensional Data: Illustration From Estimation of the Effect of Maternal Metabolites on Offspring Birthweight.Genetic epidemiology · 2026Article
- Context-Stratified Mendelian Randomization: Exploiting Regional Exposure Variation to Explore Causal Effect Heterogeneity and Nonlinearity.Statistics in medicine · 2026Article
- Mendelian randomization reveals the causal relationship between cholecystectomy and ischemic stroke.BMC neurology · 2026Article
- Polyamide-66 microplastics and early-onset ischemic stroke: a systems toxicology, multi-omics, and molecular dynamics simulation analysis.Molecular diversity · 2026Article
- Causal effects of endometriosis on serum 25-hydroxyvitamin D: Evidence from Mendelian randomization study.Medicine · 2026Article
- Integrating genetic data with biological insight: A practical guide to cis-Mendelian randomization.American journal of human genetics · 2026Review
- Triglyceride-glucose index, plasma metabolome and aortic stenosis: a Mendelian randomization analysis.Journal of cardiothoracic surgery · 2026Article
- Article
- Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites.Brain and behavior · 2026Article
- Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections.JACC. Basic to translational science · 2026Article
- Genetically Simulated GLP-1 Receptor Agonism and Cerebral Small Vessel Disease.Neurology. Genetics · 2026Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
Abstract
Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approaches for MR analysis. The recently proposed "global and individual tests for direct effects" (GLIDE) approach fits into a family of methods that aim to detect horizontal pleiotropy-at the individual single nucleotide polymorphism level and at the global level-and to adjust the analysis by removing outlying single nucleotide polymorphisms. In this commentary, we explain how existing methods can (and indeed are) being used to detect pleiotropy at the individual and global levels, although not explicitly using this terminology. By doing so, we show that the true comparator for GLIDE is not MR-Egger regression (as Dai et al., the authors of the accompanying article (Am J Epidemiol. 2018;187(12):2672-2680), claim) but rather the humble heterogeneity statistic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.