ArticlePLoS neglected tropical diseases2018
Phylogenomic analysis unravels evolution of yellow fever virus within hosts.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Assessment of the yellow fever outbreak in Angola from December 2015 through December 2016: A retrospective study.Health science reports · 2024Article
- Developing an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples.PLoS pathogens · 2023Review
- Viral intra-host evolutionary dynamics revealed via serial passage of Japanese encephalitis virusVirus evolution · 2023Article
- Article
- Yellow Fever Molecular Diagnosis Using Urine Specimens during Acute and Convalescent Phases of the Disease.Journal of clinical microbiology · 2022Article
- Article
- Assessment of two-pool multiplex long-amplicon nanopore sequencing of SARS-CoV-2.Journal of medical virology · 2022Article
- Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore Sequencing.Virologica Sinica · 2021Article
- Discriminating arboviral species.The Journal of general virology · 2021Article
- Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients.Genome medicine · 2021Article
- Difference of Intrahost Dynamics of the Second Human Pegivirus and Hepatitis C Virus in HPgV-2/HCV-Coinfected Patients.Frontiers in cellular and infection microbiology · 2021Article
- Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.PLoS neglected tropical diseases · 2020Article
- Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.Current treatment options in infectious diseases · 2020Review
- Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.Current treatment options in infectious diseases · 2020Review
- Review
- Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection.Virologica Sinica · 2019Article
- An Assessment of Amplicon-Sequencing Based Method for Viral Intrahost Analysis.Virologica Sinica · 2018Article
Corrections and comments
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Authors and funding
28 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yellow fever virus (YFV) recently reemerged in the large outbreaks in Africa and Brazil, and the first imported patients into Asia have recalled the concerns of YFV evolution. Here we show phylogenomics of YFV with serial clinical samples of the 2016 YFV infections. Phylogenetics exhibited that the 2016 strains were close to Angola 1971 strains and only three amino acid changes presented new to other lineages. Deep sequencing of viral genomes discovered 101 intrahost single nucleotide variations (iSNVs) and 234 single nucleotide polymorphisms (SNPs). Analysis of iSNV distribution and mutated allele frequency revealed that the coding regions were under purifying selection. Comparison of the evolutionary rates estimated by iSNV and SNP showed that the intrahost rate was ~2.25 times higher than the epidemic rate, and both rates were higher than the long-term YFV substitution rate, as expected. In addition, the result also hinted that short viremia duration of YFV might further hinder the evolution of YFV.
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