ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018
Regulation of regional cerebral blood flow during graded reflex-mediated sympathetic activation via lower body negative pressure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Sex-based differences in central and cerebral hemodynamic responses to lower body negative pressure (LBNP): an experimental study.European journal of applied physiology · 2026Article
- Cerebral blood flow during simulated central hypovolaemia in people with hypertension: does vertebral artery hypoplasia matter?The Journal of physiology · 2025Article
- Postural influence on intracranial fluid dynamics: an overview.Journal of physiological anthropology · 2023Review
- Influence of head-up tile and lower body negative pressure on the internal jugular vein.Physiological reports · 2022Article
- Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers.European journal of applied physiology · 2021Article
- Peaks and valleys: oscillatory cerebral blood flow at high altitude protects cerebral tissue oxygenation.Physiological measurement · 2021Article
- The effect of hypercapnia on regional cerebral blood flow regulation during progressive lower-body negative pressure.European journal of applied physiology · 2021Article
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Specific effect of hypobaria on cerebrovascular hypercapnic responses in hypoxia.Physiological reports · 2020Article
- Exercise intensity and middle cerebral artery dynamics in humans.Respiratory physiology & neurobiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of the sympathetic nervous system in cerebral blood flow (CBF) regulation remains unclear. Previous studies have primarily measured middle cerebral artery blood velocity to assess CBF. Recently, there has been a transition toward measuring internal carotid artery (ICA) and vertebral artery (VA) blood flow using duplex Doppler ultrasound. Given that the VA supplies autonomic control centers in the brainstem, we hypothesized that graded sympathetic activation via lower body negative pressure (LBNP) would reduce ICA but not VA blood flow. ICA and VA blood flow were measured during two protocols:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.