ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018
The spatial pattern of methacholine bronchoconstriction recurs when supine independently of posture during provocation but does not recur between postures.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Vaping causes an acute BMI-dependent change in pulmonary blood flow.Physiological reports · 2024Article
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Vaping disrupts ventilation-perfusion matching in asymptomatic users.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The location of lung regions with compromised ventilation (often called ventilation defects) during a bronchoconstriction event may be influenced by posture. We aimed to determine the effect of prone versus supine posture on the spatial pattern of methacholine-induced bronchoconstriction in six healthy adults (ages 21-41, 3 women) using specific ventilation imaging. Three postural conditions were chosen to assign the effect of posture to the drug administration and/or imaging phase of the experiment: supine methacholine administration followed by supine imaging, prone methacholine administration followed by supine imaging, and prone methacholine administration followed by prone imaging. The two conditions in which imaging was performed supine had similar spatial patterns of bronchoconstriction despite a change in posture during methacholine administration; the odds ratio for recurrent constriction was mean (SD) = 7.4 (3.9). Conversely, dissimilar spatial patterns of bronchoconstriction emerged when posture during imaging was changed; the odds ratio for recurrent constriction between the prone methacholine/supine imaging condition and the prone methacholine/prone imaging condition was 1.2 (0.9). Logistic regression showed that height above the dependent lung border was a significant negative predictor of constriction in the two supine imaging conditions (
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