ArticleMolecular biology of the cell2018
Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy.
Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Aging in Spaceflight, Oxidative Stress, and Microbiome Dysbiosis: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Nervonic Acid Prevents HFD-Induced Metabolic Dysfunction and Is Associated with Gut Microbiota Remodeling.Metabolites · 2026Article
- Review
- Article
- Peroxisomal cholesterol metabolism regulates yap-signaling, which maintains intestinal epithelial barrier function and is altered in Crohn's disease.Cell death & disease · 2024Article
- The Wnt/β-catenin pathway is important for replication of SARS-CoV-2 and other pathogenic RNA viruses.Npj viruses · 2024Article
- Gut redox and microbiome: charting the roadmap to T-cell regulation.Frontiers in immunology · 2024Review
- A foundational approach to culture and analyze malnourished organoids.Gut microbes · 2023Article
- The Influence of Gut Microbiota on Oxidative Stress and the Immune System.Biomedicines · 2023Review
- Towards early detection of neurodegenerative diseases: A gut feeling.Frontiers in cell and developmental biology · 2023Review
- The coordinated management of ribosome and translation during injury and regeneration.Frontiers in cell and developmental biology · 2023Review
- The Nitric Oxide Donor,Frontiers in cell and developmental biology · 2021Article
- Peroxisomes in host defense.PLoS pathogens · 2020Article
- Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.Scientific reports · 2020Article
- Rosy Beginnings: Studying Peroxisomes inFrontiers in cell and developmental biology · 2020Review
- The Intestine ofMicroorganisms · 2019Review
- Peroxisomes and Innate Immunity: Antiviral Response and Beyond.International journal of molecular sciences · 2019Review
- Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease.Histochemistry and cell biology · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The gut has a central role in digestion and nutrient absorption, but it also serves in defending against pathogens, engages in mutually beneficial interactions with commensals, and is a major source of endocrine signals. Gut homeostasis is necessary for organismal health and changes to the gut are associated with conditions like obesity and diabetes and inflammatory illnesses like Crohn's disease. We report that peroxisomes, organelles involved in lipid metabolism and redox balance, are required to maintain gut epithelium homeostasis and renewal in Drosophila and for survival and development of the organism. Dysfunctional peroxisomes in gut epithelial cells activate Tor kinase-dependent autophagy that increases cell death and epithelial instability, which ultimately alter the composition of the intestinal microbiota, compromise immune pathways in the gut in response to infection, and affect organismal survival. Peroxisomes in the gut effectively function as hubs that coordinate responses from stress, metabolic, and immune signaling pathways to maintain enteric health and the functionality of the gut-microbe interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.