Evidence map›Paper›PMID 30188693›Full record

ArticleACS chemical neuroscience2019

Diarylureas Containing 5-Membered Heterocycles as CB

Thuy Nguyen, Thomas F Gamage, Ann M Decker, Nadezhda German, Tiffany L Langston, Charlotte E Farquhar, Terry P Kenakin, Jenny L Wiley, Brian F Thomas, Yanan Zhang

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thuy NguyenResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Thomas F GamageResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Ann M DeckerResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Nadezhda GermanResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Tiffany L LangstonResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Charlotte E FarquharResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Terry P KenakinDepartment of Pharmacology , University of North Carolina , Chapel Hill , North Carolina 27599 , United States.
Jenny L WileyResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Brian F ThomasResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Yanan ZhangResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.ORCID 0000-0001-7153-4358

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
THC RECEPTORSR37DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, BILLY R · 1997 to 2006
$2.8M
Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA040693NIDA NIH HHS R37 DA003672
6 · The paper itself

Abstract

Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB

Indexed as

Allosteric RegulationAnimalsGuanosine 5'-O-(3-Thiotriphosphate)HEK293 CellsHumansPhenylurea CompoundsPyridinesReceptor, Cannabinoid, CB1Signal TransductionStructure-Activity Relationship1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)ureaGuanosine 5'-O-(3-Thiotriphosphate)Phenylurea CompoundsPyridinesReceptor, Cannabinoid, CB1allosteric modulatorsCB1 receptordiarylureafive-membered heterocyclesPSNCBAM-1structure−activity relationship

Identifiers

PMID30188693
PMCPMC6426682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.