ArticleAlzheimer disease and associated disorders
Nutritional Status is Associated With Severe Dementia and Mortality: The Cache County Dementia Progression Study.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies.BMJ (Clinical research ed.) · 2020Pooled it
- Are ketogenic diets promising for Alzheimer's disease? A translational review.Alzheimer's research & therapy · 2020Pooled it
- Trial
- Association between geriatric malnutrition and the risk of dementia: a retrospective cross-sectional cohort study in Uganda.BMC geriatrics · 2026Article
- Nutritional status, Mediterranean diet adherence, and quality of life in older adults with dementia: A cross-sectional study.Journal of Alzheimer's disease : JAD · 2026Article
- Clinical implications of malnutrition in Huntington's disease progression: evidence from a Chinese cohort and Mendelian randomization.Frontiers in nutrition · 2026Article
- Nonagenarians with major neurocognitive disorder hospitalized in a high-complexity hospital.Dementia & neuropsychologia · 2026Article
- The Impact of Frailty, Activity of Daily Living, and Malnutrition on Mortality in Older Adults with Cognitive Impairment and Dementia.Nutrients · 2025Article
- Uncovering nutrition needs in dyads of caregivers and persons with dementia.Journal of Alzheimer's disease : JAD · 2025Article
- Improving Mealtime Independence for People With Dementia Living in Nursing Homes: A Pilot Study.Nursing research and practice · 2025Article
- Impact of dementia and mild cognitive impairment on bone health in older people.Aging clinical and experimental research · 2024Review
- The association between malnutrition, depression and cognitive decline in free-living elderly people in Cyprus: a cross-sectional study.BMC public health · 2024Article
- Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer's Disease.Nutrients · 2024Article
- COVID-19 outcomes among patients with dementia and age-matched controls who were hospitalized in 21 US health-care systems.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- All GLP-1 Agonists Should, Theoretically, Cure Alzheimer's Dementia but Dulaglutide Might Be More Effective Than the Others.Journal of clinical medicine · 2024Review
- An investigation into the potential association between nutrition and Alzheimer's disease.Frontiers in nutrition · 2024Article
- Targeted plasma metabolomics reveals potential biomarkers of the elderly with mild cognitive impairment in Qingdao rural area.Frontiers in aging neuroscience · 2024Article
- Palliative Care in Nursing Home Residents with Young-Onset Dementia: Professional and Family Caregiver Perspectives.Journal of Alzheimer's disease : JAD · 2024Observational
- Malnutrition and neuropsychiatric symptoms in dementia: the Cache County Dementia Progression Study.International psychogeriatrics · 2023Observational
- Nutrition in Alzheimer's disease: a review of an underappreciated pathophysiological mechanism.Science China. Life sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeStudies have reported faster cognitive/functional decline in persons with dementia (PWD) with malnutrition. We investigated whether baseline nutritional status predicted severe dementia and mortality in a population-based sample. PATIENTS: A maximum of 300 PWD were assessed annually for up to 8.6 years.
methodsNutritional status was assessed using a modified Mini-Nutritional Assessment (mMNA). Severe dementia was defined as: "severe" rating on the Clinical Dementia Rating or Mini-Mental State Examination score ≤10. Using Cox proportional hazards models, we examined the association between baseline mMNA score (or its subcomponents) with each outcome. Covariates included demographics; dementia onset age, type, and duration; APOE genotype; and residency with caregiver.
resultsCompared with "well-nourished," "malnourished" PWD had 3-4 times the hazard of severe dementia [hazard ratio (HR), 4.31; P=0.014] and death (HR, 3.04; P<0.001). Those "at risk for malnutrition" had twice the hazard of severe dementia (HR, 1.98; P=0.064) and 1.5 times the hazard of death (HR, 1.46; P=0.015). mMNA subcomponents of food group intake, weight loss, body mass index, mobility, health status, protein consumption, and mid-arm circumference predicted one or both outcomes.
conclusionsNutritional status is an important predictor of clinical outcomes in dementia and may provide an avenue for intervention.
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