Evidence map›Paper›PMID 30187877›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018

[2-deoxyglucose inhibits angiogenesis of rheumatoid arthritis via activating AMPK pathway].

Ying Wang, Yingmei Wei, Xiu Cheng, Xiaojin Sun, Linyan Ma, Yining Song, Jing Zhou, Fang Wei, Hao Liu

Abstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying WangFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Yingmei WeiFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Xiu ChengFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Xiaojin SunFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Linyan MaFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Yining SongFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Jing ZhouFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Fang WeiFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Hao LiuFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the effects of 2-deoxyglucose inhibiting synovial pannus of adjuvant arthritis rats and to explore its potential mechanism of inhibiting angiogenesis by investigating proliferation, migration and matrigel tube formation assay

methodsThe effect of 2-DG on synovial pannus was evaluated by histopathology of HE staining; HUVEC proliferation was determined by CCK-8 method; migration of FLS were determined by transwell;

results2-DG (200 mg/kg) obviously decreased appearance of synovial pannus (

conclusionsActivating AMPK pathway and decreasing expression of Bcl-2 may the potential mechanism by which 2-DG contributes to anti-angiogenesis and effects of inhibiting proliferation, migration and tube number of HUVEC.

Indexed as

AMP-Activated Protein Kinase KinasesAngiogenesis InhibitorsAnimalsArthritis, ExperimentalArthritis, RheumatoidCell MovementCell ProliferationDeoxyglucoseEnzyme ActivationEnzyme InhibitorsHumansHuman Umbilical Vein Endothelial CellsNeovascularization, PathologicProtein KinasesRatsSynovial MembraneAMP-Activated Protein Kinase KinasesAngiogenesis InhibitorsDeoxyglucoseEnzyme InhibitorsProtein Kinases2-deoxyglucoseAMPK pathwayangiogenesisglycolysisrheumatoid arthritis

Identifiers

PMID30187877
PMCPMC6744039
OpenAlexW2997328820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.