ArticleJournal of Zhejiang University. Science. B
In vitro culture of mammalian inner ear hair cells.
Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Inner ear organoids: Recent progress and potential applications.Fundamental research · 2025Review
- Development of the inner ear and regeneration of hair cells after hearing impairment.Fundamental research · 2025Review
- Down-film as a new non-frame porous material for sound absorption.Scientific reports · 2024Article
- Advancements in inner ear development, regeneration, and repair through otic organoids.Current opinion in genetics & development · 2022Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Auditory function in vertebrates depends on the transduction of sound vibrations into electrical signals by inner ear hair cells. In general, hearing loss resulting from hair cell damage is irreversible because the human ear has been considered to be incapable of regenerating or repairing these sensory elements following severe injury. Therefore, regeneration and protection of inner ear hair cells have become an exciting, rapidly evolving field of research during the last decade. However, mammalian auditory hair cells are few in number, experimentally inaccessible, and barely proliferate postnatally in vitro. Various in vitro primary culture systems of inner ear hair cells have been established by different groups, although many challenges remain unresolved. Here, we briefly explain the structure of the inner ear, summarize the published methods of in vitro hair cell cultures, and propose a feasible protocol for culturing these cells, which gave satisfactory results in our study. A better understanding of in vitro hair cell cultures will substantially facilitate research involving auditory functions, drug development, and the isolation of critical molecules involved in hair cell biology.
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