Evidence map›Paper›PMID 30187654›Full record

ArticlePhysiological reports2018

Assessment of diastolic function and atrial remodeling by MRI - validation and correlation with echocardiography and filling pressure.

Felicia Seemann, Lauren A Baldassarre, Fiorella Llanos-Chea, Ricardo A Gonzales, Karl Grunseich, Chenxi Hu, Lissa Sugeng, Judith Meadows, Einar Heiberg, Dana C Peters

Open access · goldAbstract readValidation Study
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  7. Association of cardiovascular magnetic resonance diastolic indices with arrhythmia in repaired Tetralogy of Fallot.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
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  8. AUTOMATED MEASUREMENTS OF MITRAL AND TRICUSPID ANNULAR DIMENSIONS IN CARDIOVASCULAR MAGNETIC RESONANCE.Proceedings. IEEE International Symposium on Biomedical Imaging · 2022
    Article
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  11. MVnet: automated time-resolved tracking of the mitral valve plane in CMR long-axis cine images with residual neural networks: a multi-center, multi-vendor study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
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  19. Mapping and Imaging in Non-paroxysmal AF.Arrhythmia & electrophysiology review · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Felicia SeemannDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Lauren A BaldassarreDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Fiorella Llanos-CheaDepartment of Cardiology, Yale University, New Haven, Connecticut.ORCID 0000-0003-4432-1263
Ricardo A GonzalesDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Karl GrunseichDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Chenxi HuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Lissa SugengSection of Cardiovascular Medicine, Department of Medicine, Yale University, New Haven, Connecticut.
Judith MeadowsSection of Cardiovascular Medicine, Department of Medicine, Yale University, New Haven, Connecticut.
Einar HeibergDepartment of Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden.
Dana C PetersDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Yale University · USLund University · SEUniversity of California, San Francisco · US

Funding

Detection of Atrial Remodeling by MRI: Validation and Emerging SignificanceR01HL122560 · NHLBI · YALE UNIVERSITY · PI PETERS, DANA C · 2015 to 2018
$1.7M
NHLBI NIH HHS R01 HL122560NHLBI NIH HHS R01HL122560
6 · The paper itself

Abstract

Atrial fibrosis can be estimated noninvasively by magnetic resonance imaging (MRI) using late gadolinium enhancement (LGE), but diastolic dysfunction is clinically assessed by transthoracic echocardiography (TTE), and rarely by MRI. This study aimed to evaluate well-established diastolic parameters using MRI, and validate them with TTE and left ventricular (LV) filling pressures, and to study the relationship between left atrial (LA) remodeling and parameters of diastolic function. The study retrospectively included 105 patients (53 ± 16 years, 39 females) who underwent 3D LGE MRI between 2012 and 2016. Medical charts were reviewed for the echocardiographic diastolic parameters E, A, and e' by TTE, and pressure catheterizations. E and A were measured from in-plane phase-contrast cardiac MRI images, and e' by feature-tracking, and validated with TTE. Interobserver and intraobserver variability was examined. Furthermore, LA volumes, function, and atrial LGE was correlated with diastolic parameters. Evaluation of e' in MRI had strong agreement with TTE (r = 0.75, P < 0.0001), and low interobserver and intraobserver variability. E and A by TTE showed strong agreement to MRI (r = 0.77, P = 0.001; r = 0.73, P = 0.003, for E and A, respectively). Agreement between E/e' by TTE and MRI was strong (r = 0.85, P = 0.0004), and E/e' by TTE correlated moderately to invasive pressures (r = 0.59, P = 0.03). There was a strong relationship between LA LGE and pulmonary capillary wedge pressure (r = 0.81, P = 0.01). In conclusion, diastolic parameters can be measured with good reproducibility by cardiovascular MRI. LA LGE exhibited a strong relationship with pulmonary capillary wedge pressure, an indicator of diastolic function.

Indexed as

Atrial RemodelingDiastoleAdultAgedContrast MediaEchocardiographyFemaleFibrosisGadoliniumHeart DiseasesHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsContrast MediaGadoliniumCardiovascular magnetic resonance imagingdiastolic functionechocardiographyleft atrial late gadolinium enhancementleft ventricular filling pressure

Identifiers

PMID30187654
PMCPMC6125607
OpenAlexW2892330557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.