Trial reportActa ophthalmologica2019
The impact of extent of internal limiting membrane peeling on anatomical outcomes of macular hole surgery: results of a 54-week randomized clinical trial.
Trial report in Acta ophthalmologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Internal limiting membrane peel size and macular hole surgery outcome: a systematic review and individual participant data study of randomized controlled trials.Eye (London, England) · 2025Pooled it
- Quantifying optimal inner limiting membrane peeling in macular hole surgery: a machine learning framework for predictive modeling and schematic visualization.BMC medical informatics and decision making · 2025Article
- Controversies, consensuses, and guidelines on macular hole surgery by the Asia-Pacific Vitreo-retina Society (APVRS) and the Asia-Pacific Academy of Professors in Ophthalmology (AAPPO).Eye and vision (London, England) · 2025Review
- Predicting Visual Recovery in Long-Standing Macular Holes: Surgical Strategies and Role of Optical Coherence Tomography Biomarkers.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Outcomes of amniotic membrane transplant for refractory macular hole - an optical coherence tomography and autofluorescence long-term study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Supervised machine learning statistical models for visual outcome prediction in macular hole surgery: a single-surgeon, standardized surgery study.International journal of retina and vitreous · 2025Article
- Machine Learning and Optical-Coherence-Tomography-Derived Radiomics Analysis to Predict the Postoperative Anatomical Outcome of Full-Thickness Macular Hole.Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study.BMC ophthalmology · 2023Article
- Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes.International journal of retina and vitreous · 2023Review
- Development and validation of a deep learning system to classify aetiology and predict anatomical outcomes of macular hole.The British journal of ophthalmology · 2023Article
- Comparison of Idiopathic Macular Hole Interventions Using Frequency Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography.Disease markers · 2022Article
- Internal limiting membrane peeling for large macular hole: Tailoring the rhexis to the shape of the hole.Indian journal of ophthalmology · 2022Article
- Severe phimosis-like epiretinal membrane proliferation following internal limiting membrane peeling for macular hole.International journal of ophthalmology · 2022Article
- Negative effects of enlarging internal limiting membrane peeling for idiopathic macular hole surgery.International journal of ophthalmology · 2022Article
- Macular Holes: Main Clinical Presentations, Diagnosis, and Therapies.Journal of ophthalmology · 2022Review
- Internal limiting membrane peeling in macular hole surgery.German medical science : GMS e-journal · 2022Review
- Machine learning-based prediction of anatomical outcome after idiopathic macular hole surgery.Annals of translational medicine · 2021Article
- Anatomical and Functional Outcomes in Eyes with Idiopathic Macular Holes that Underwent Surgery Using the Inverted Internal Limiting Membrane (ILM) Flap Technique Versus the Conventional ILM Peeling Technique.Advances in therapy · 2021Article
- Factors Associated with Anatomic Failure and Hole Reopening after Macular Hole Surgery.Journal of ophthalmology · 2021Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
purposeTo compare the anatomical outcomes of different extents of internal limiting membrane (ILM) peeling in idiopathic macular hole surgery.
methodsProspective, parallel-group, randomized clinical trial. A total of 121 eyes of 121 patients with idiopathic macular hole underwent pars plana vitrectomy, and peeling of the ILM with a diameter of two disk diameters (DD) or 4DD based on randomization. The main outcome was the proportion of eyes with complete hole closure at 12 months. The second outcome was the hole closure grading stratified by macular hole closure index (MHCI) at each visit.
resultsAt 12 months, there was no significant difference in anatomical outcomes with complete closure achieved in 52 (82.5%) of 63 eyes in the 2DD group and 53 (91.4%) of 58 eyes in the 4DD group (p = 0.15). For subjects with MHCI ≤0.5 (n = 24), complete closure rate was significantly lower in the 2DD group compared to the 4DD group (p = 0.012; 18.2% versus 75.9%, respectively). Average BCVA was lower in 2DD group than 4DD group (p = 0.014). By contrast, when MHCI was >0.5, the complete closure rate between the two groups showed no significant difference: 96.2% (50 patients) versus 95.6% (43 patients), respectively (p = 0.185).
conclusionIn patients with idiopathic full-thickness macular hole and MHCI ≤0.5, a larger ILM peel of 4DD tends to achieve better anatomical outcomes than a more limited 2DD peel.
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