Evidence map›Paper›PMID 30187415›Full record

ArticleEnvironmental science and pollution research international2018

Evaluation of (-)-borneol derivatives against the Zika vector, Aedes aegypti and a non-target species, Artemia sp.

Rafaela K V Nunes, Ulisses N Martins, Thaysnara B Brito, Angelita Nepel, Emmanoel V Costa, Andersson Barison, Roseli L C Santos, Sócrates C H Cavalcanti

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rafaela K V NunesMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil.
Ulisses N MartinsMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil.
Thaysnara B BritoMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil.
Angelita NepelNuclear Magnetic Resonance Laboratory, Chemistry Department, Federal University of Paraná, PO Box 19081, Curitiba, PR, 81531-990, Brazil.
Emmanoel V CostaChemistry Department, Institute of Applied Sciences, Federal University of Amazonas, Manaus, Brazil.
Andersson BarisonNuclear Magnetic Resonance Laboratory, Chemistry Department, Federal University of Paraná, PO Box 19081, Curitiba, PR, 81531-990, Brazil.
Roseli L C SantosParasitology Laboratory, Morphology Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil.
Sócrates C H CavalcantiMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil. socratescavalcanti@yahoo.com.br.ORCID http://orcid.org/0000-0001-6138-8051
Universidade Federal de Sergipe · BRUniversidade Federal do Paraná · BRUniversidade Federal do Amazonas · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 47601/2013-2
6 · The paper itself

Abstract

Zika, dengue, and chikungunya are vector-borne diseases of pronounced concern transmitted by the mosquito Aedes aegypti Linn. (Diptera: Culicidae). The most important method to avoid outbreaks is to control mosquito spreading by the employment of insecticides and larvicides. Failure to control mosquito dispersal is mostly accounted to Ae. aegypti resistance to currently available larvicides and insecticides, encouraging the development of novel pesticides. In addition, the excessive use of larvicides poses serious threats to human health and the environment. Evaluation of natural products as larvicides in an attempt to overcome this situation is often found in the literature because products originated from nature are considered less toxic to non-target species and more eco-friendly. (-)-Borneol is a bicyclic monoterpene present in essential oils with moderate larvicidal activity. On account of these facts, it was of our interest to synthesize (-)-borneol ester derivatives aiming to study its structure-activity relationships against Ae. aegypti larvae. With the goal to estimate toxicity to a non-target species, evaluation of the lethal concentration 50% (LC

Indexed as

AedesAnimalsArtemiaCamphanesEstersInsecticidesLarvaLethal Dose 50Mosquito VectorsZika Virus InfectionCamphanesEstersInsecticidesisoborneolBorneol estersDengueLarvicidal activityMicrocephalyQSARTerpenes

Identifiers

PMID30187415
OpenAlexW2892074311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.