Evidence map›Paper›PMID 30187297›Full record

ArticleMolecular diversity2019

Amino acids and peptides as reactants in multicomponent reactions: modification of peptides with heterocycle backbones through combinatorial chemistry.

Maryam Nourisefat, Farhad Panahi, Ali Khalafi-Nezhad

Abstract read
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In one paragraph

Article in Molecular diversity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maryam NourisefatDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran.
Farhad PanahiDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran. fpanahi@aut.ac.ir.ORCID http://orcid.org/0000-0003-0420-4409
Ali Khalafi-NezhadDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran. khalafi@chem.susc.ac.ir.
Shiraz University · IRAmirkabir University of Technology · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, amino acids and peptides were used as reactants in a Hantzsch multicomponent reaction in order to synthesize new structurally diverse molecules containing these synthons. As well, an applicable strategy for modification of these natural molecules with heterocycle backbones such as pyrimidine, xanthene and acridine is introduced. Using this method, a set of new amino acid- and peptide-functionalized heterocycles were synthesized in good to excellent yields under mild conditions. Furthermore, carbohydrates were used as substrates in the synthesis of some derivatives. Overall, this methodology allows the possibility of synthesis of large numbers of natural product-based libraries, using amino acids, peptides and carbohydrates through combinatorial chemistry.

Indexed as

Amino AcidsCombinatorial Chemistry TechniquesHeterocyclic CompoundsPeptidesAmino AcidsHeterocyclic CompoundsPeptidesAmino acidsCombinatorial chemistryHeterocyclesMulticomponent reactionsPeptides

Identifiers

PMID30187297
OpenAlexW2891332697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.