Evidence map›Paper›PMID 30187223›Full record

ArticleJournal of mathematical biology2019

Sensitivity analysis of the Poisson Nernst-Planck equations: a finite element approximation for the sensitive analysis of an electrodiffusion model.

Ibrahima Dione, Nicolas Doyon, Jean Deteix

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In one paragraph

Article in Journal of mathematical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ibrahima DioneDépartement de mathématiques et statistique/Groupe Interdisciplinaire de Recherche en Éléments Finis (GIREF), Université Laval, Pavillon Vachon, 1045 Avenue de la médecine, Québec, QC, Canada.
Nicolas DoyonDépartement de mathématiques et statistique/Groupe Interdisciplinaire de Recherche en Éléments Finis (GIREF), Université Laval, Pavillon Vachon, 1045 Avenue de la médecine, Québec, QC, Canada.
Jean DeteixDépartement de mathématiques et statistique/Groupe Interdisciplinaire de Recherche en Éléments Finis (GIREF), Université Laval, Pavillon Vachon, 1045 Avenue de la médecine, Québec, QC, Canada. jean.deteix@mat.ulaval.ca.ORCID 0000-0001-9463-2057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological structures exhibiting electric potential fluctuations such as neuron and neural structures with complex geometries are modelled using an electrodiffusion or Poisson Nernst-Planck system of equations. These structures typically depend upon several parameters displaying a large degree of variation or that cannot be precisely inferred experimentally. It is crucial to understand how the mathematical model (and resulting simulations) depend on specific values of these parameters. Here we develop a rigorous approach based on the sensitivity equation for the electrodiffusion model. To illustrate the proposed methodology, we investigate the sensitivity of the electrical response of a node of Ranvier with respect to ionic diffusion coefficients and the membrane dielectric permittivity.

Indexed as

Models, NeurologicalAnimalsComputational BiologyComputer SimulationDiffusionElectrophysiological PhenomenaFinite Element AnalysisIon TransportMathematical ConceptsPoisson DistributionRanvier's NodesElectrodiffusionFinite elementsIonic concentrationsNode of RanvierSensitivity equation method

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.