ArticleBrain structure & function2018
Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Gradient Organization of Space, Time, and Numbers in the Brain: A Meta-analysis of Neuroimaging Studies.Neuropsychology review · 2024Pooled it
- Functional neuroimaging in patients with catatonia: A systematic review.Journal of psychosomatic research · 2024Pooled it
- The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications.Frontiers in neurology · 2021Pooled it
- Effect of meditation on clinical symptoms and gray matter volume in chronic schizophrenia: a randomized controlled trial.European archives of psychiatry and clinical neuroscience · 2026Trial
- Cortical activity during sensorial tactile stimulation in healthy adults through Vojta therapy. A randomized pilot controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Distinct cortical excitability and connectivity profiles within the human SMA complex.bioRxiv : the preprint server for biology · 2026Article
- Continuous Theta Burst to Supplementary Motor Area Modulates Groove.Annals of the New York Academy of Sciences · 2026Article
- Revised cytoarchitectonic mapping of the human premotor cortex identifies seven areas and refines the localisation of frontal eye fields.Communications biology · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Deficits of Attention and Working Memory in Patients with Gliomas of Supplementary Motor Area.Journal of clinical medicine · 2025Article
- Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis.Scientific reports · 2025Article
- Supplementary motor area in speech initiation: A large-scale intracranial EEG evaluation of stereotyped word articulation.iScience · 2025Article
- Role for Left Dorsomedial Prefrontal Cortex in Self-Generated, but not Externally Cued, Language Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- A Graph-Based Statistical Approach to Identifying Functional Connectivity Networks in Patients with Traumatic Brain Injury.Iranian journal of child neurology · 2025Article
- Functional Connectivity Profiles of Ten Sub-Regions within the Premotor and Supplementary Motor Areas: Insights into Neurophysiological Integration.Diagnostics (Basel, Switzerland) · 2024Article
- Harnessing the frontal aslant tract's structure to assess its involvement in cognitive functions: new insights from 7-T diffusion imaging.Scientific reports · 2024Article
- A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits.Brain and behavior · 2024Review
- Differential Cortical and Subcortical Activations during Different Stages of Muscle Control: A Functional Magnetic Resonance Imaging Study.Brain sciences · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The dorsal mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence between the two subregions. However, a microstructural map of these areas obtained in a representative sample of brains in a stereotaxic reference space is still lacking. In the present study we show that the dorsal mesial frontal motor cortex comprises two microstructurally different brain regions: area SMA and area pre-SMA. Area-specific cytoarchitectonic patterns were studied in serial histological sections stained for cell bodies of ten human postmortem brains. Borders of the two cortical areas were identified using image analysis and statistical features. The 3D reconstructed areas were transferred to a common reference space, and probabilistic maps were calculated by superimposing the individual maps. A coordinate-based meta-analysis of functional imaging data was subsequently performed using the two probabilistic maps as microstructurally defined seed regions. It revealed that areas SMA and pre-SMA were strongly co-activated with areas in precentral, supramarginal and superior frontal gyri, Rolandic operculum, thalamus, putamen and cerebellum. Both areas were related to motor functions, but area pre-SMA was involved in more complex processes such as learning, cognitive processes and perception. The here described subsequent analyses led to converging evidence supporting the microstructural, and functional segregation of areas SMA and pre-SMA, and maps will be made available to the scientific community to further elucidate the microstructural substrates of motor and cognitive control.
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