Evidence map›Paper›PMID 30187180›Full record

ArticleMetabolic brain disease2018

EGb761 improves the cognitive function of elderly db/db

Zhu-Fei Guan, Xiao-Ming Zhang, Ying-Hong Tao, Yu Zhang, Yan-Yan Huang, Gang Chen, Wei-Jun Tang, Gang Ji, Qi-Lin Guo, Ming Liu and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. The active ingredient of Ginkgo biloba extract (quercetin) improved HIn vitro cellular & developmental biology. Animal · 2025
    Article
  2. Role of Necroptosis and Neuroinflammation in CSVD-Associated Cognitive Decline in db/db Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Iranian journal of basic medical sciences · 2020
    Article
  8. Cytotoxic effect ofHeliyon · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 1 country.

Zhu-Fei GuanDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiao-Ming ZhangDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ying-Hong TaoDepartment of Medical Examination Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yu ZhangDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yan-Yan HuangDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Gang ChenDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wei-Jun TangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Gang JiState Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Qi-Lin GuoState Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Ming LiuState Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Qian ZhangState Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Na-Na WangDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhong-Yu YuDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Hao-YangDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Guo-Feng WuDepartment of Emergency Neurology, Guiyang Medical University, Guiyang, 550004, China.
Zhou-Ping TangDepartment of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430000, China.
Zun-Guo DuDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xi-Liang ShangDepartment of Sport Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ying-Chao LiuDepartment of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
Guang-Hai MeiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. meighai@126.com.
Jing-Chun GuoState Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. jingchunguo@shmu.edu.cn.
Hou-Guang ZhouDepartment of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. zhg7376@163.com.
Huashan Hospital · CNFudan University · CNShanghai Medical College of Fudan University · CNState Key Laboratory of Medical NeurobiologyGuiyang Medical University · CNShandong University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db

Indexed as

AgingAnimalsBeclin-1Cognitive DysfunctionDiabetes Mellitus, ExperimentalDose-Response Relationship, DrugGinkgo bilobaGinkgo ExtractMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutNF-kappa BPlant ExtractsSignal TransductionBeclin-1Ginkgo biloba extractGinkgo ExtractNF-kappa BPlant ExtractsAutophagyBeclin-1Cognitive functionEGb761LC3-II/INF-κB protein

Identifiers

PMID30187180
PMCPMC6244769
OpenAlexW2891461937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.