ArticleIranian journal of basic medical sciences2018
Cytotoxic effect of pyocyanin on human pancreatic cancer cell line (Panc-1).
Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Anti-pyocyanin Antibody Exhibits Cytotoxicity Protective Effects on Macrophages: A Promising Innovative Therapeutic Approach forACS pharmacology & translational science · 2025Article
- Multi-walled carbon nanotubes as reusable boosters of pyocyanin production for anticancer research.Applied microbiology and biotechnology · 2025Article
- Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review).Oncology letters · 2025Review
- AvirulentmicroLife · 2025Article
- Article
- Pigments from pathogenic bacteria: a comprehensive update on recent advances.World journal of microbiology & biotechnology · 2024Review
- Transforming microbial pigment into therapeutic revelation: extraction and characterization of pyocyanin from Pseudomonas aeruginosa and its therapeutic potential as an antibacterial and anticancer agent.Microbial cell factories · 2024Article
- A biomedical perspective of pyocyanin from Pseudomonas aeruginosa: its applications and challenges.World journal of microbiology & biotechnology · 2024Review
- Article
- Molecular and biological characterization of pyocyanin from clinical and environmental Pseudomonas aeruginosa.Microbial cell factories · 2023Article
- Pseudomonas aeruginosa's greenish-blue pigment pyocyanin: its production and biological activities.Microbial cell factories · 2023Review
- Bacterial Pigments and Their Multifaceted Roles in Contemporary Biotechnology and Pharmacological Applications.Microorganisms · 2023Review
- The two faces of pyocyanin - why and how to steer its production?World journal of microbiology & biotechnology · 2023Review
- The Influence of Hydrodynamic Conditions in a Laboratory-Scale Bioreactor onMicroorganisms · 2022Article
- A purified and lyophilized Pseudomonas aeruginosa derived pyocyanin induces promising apoptotic and necrotic activities against MCF-7 human breast adenocarcinoma.Microbial cell factories · 2022Article
- Pathogenesis of plant-associated Pseudomonas aeruginosa in Caenorhabditis elegans model.BMC microbiology · 2022Article
- Application of Magnetically Assisted Reactors for Modulation of Growth and Pyocyanin Production byFrontiers in bioengineering and biotechnology · 2022Article
- Quorum Sensing Inhibitors to QuenchPharmaceuticals (Basel, Switzerland) · 2021Review
- Natural Pigments of Bacterial Origin and Their Possible Biomedical Applications.Microorganisms · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPyocyanin, a blue-green pigment produced by MATERIALS AND
methodsPolymerase Chain Reaction (PCR) was applied to confirm the existence of a specific pyocyanin producing gene (phzM). The pigment was then characterized by UV-visible, FT-IR, and HPLC analysis. Panc-1 cells were treated by different concentrations of pyocyanin and their cytotoxic effect as well as the induction of apoptosis/necrosis were evaluated by XTT assay and flow cytometry.
resultsAn overnight pyocyanin treatment resulted in significant cell reduction in a concentration-dependent manner. Inhibition rate of 6 mg.ml-1 pyocyanin (the highest concentration) extracted from clinical and soil isolates of
conclusionWe reported, for the first time, cytotoxic effects of pyocyanin against human pancreatic cancer cell line. Considering this effect of the pigment, study on pyocyanin as a potential anti-tumor biodrug requires further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.