ArticleExperimental and therapeutic medicine2018
Association of cytokine gene polymorphisms with osteoarthritis susceptibility.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- The association of antihistamines and new-onset osteoarthritis in patients with autoimmune disease: a population-based cohort study.Frontiers in immunology · 2025Article
- The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis.BMC musculoskeletal disorders · 2024Article
- Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.BMC medical genomics · 2023Article
- Increased risk of osteoarthritis in patients with atopic disease.Annals of the rheumatic diseases · 2023Article
- IL-4 Predicts the Efficacy of a Candidate Antioxycodone Vaccine and Alters Vaccine-Specific Antibody-Secreting Cell Proliferation in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Biosensing chips for cancer diagnosis and treatment: a new wave towards clinical innovation.Cancer cell international · 2022Review
- The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation.Biomaterials research · 2022Review
- The effects of metformin in the treatment of osteoarthritis: Current perspectives.Frontiers in pharmacology · 2022Review
- Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats.Veterinary sciences · 2021Article
- Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.Oxidative medicine and cellular longevity · 2021Review
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- Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.PloS one · 2021Article
- SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Review
- Effect of Acute and Prolonged Inflammation on the Gene Expression of Proinflammatory Cytokines and Their Receptors in the Anterior Pituitary Gland of Ewes.International journal of molecular sciences · 2020Article
- TLR-4, TLR-5 and IRF4 are diagnostic markers of knee osteoarthritis in the middle-aged and elderly patients and related to disease activity and inflammatory factors.Experimental and therapeutic medicine · 2020Article
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- Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives.Frontiers in pharmacology · 2020Review
- A Perspective on Emerging Therapeutic Interventions for COVID-19.Frontiers in public health · 2020Review
- Elevated reproductive toxicity effects of diclofenac after withdrawal: Investigation of the therapeutic role of melatonin.Toxicology reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a multifactorial disease characterized by low-grade inflammatory processes that are mediated initially by the cells and factors of the innate immune system. In addition to their key role in inflammation, cytokines contribute to the pathogenesis of OA through angiogenesis and chemotaxis. The purpose of the present case-control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL-4R -3223C>T (rs2057768), IL-8 -251T>A (rs4073), IL-10 -1082A>G (rs1800896) and TNF -A-308G>A (rs1800629) with OA susceptibility. Genomic DNA was isolated from blood samples collected from 305 Romanian subjects (90 patients with OA and 215 controls) and the genotyping of the SNPs was performed by TaqMan allelic discrimination polymerase chain reaction using predesigned assays. Our data indicated a significant association for IL-4R rs2057768 C>T SNP. The subjects that carried the CT genotype were at a higher risk for OA (OR 2.03, 95% CI: 1.21-3.42, P=0.007) compared with those that had the CC genotype. Furthermore, the carriers of the T allele were at a 1.9 fold higher risk for OA (OR 1.92; 95% CI, 1.17-3.17; P=0.009) in a dominant model. The association remained significant only for knee OA in the subgroups analysis. No correlations were observed between the other remaining SNPs and OA. The results suggested that the IL-4R rs2057768 SNP could contribute to OA susceptibility in the Romanian population, providing novel evidence for the involvement of IL-4/IL-4R pair in the pathogenesis of OA.
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