ArticleExperimental and therapeutic medicine2018
The relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 34 citations in OpenAlex.
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- Machine learning-based models to predict type 2 diabetes combined with coronary heart disease and feature analysis-based on interpretable SHAP.Acta diabetologica · 2025Article
- Prognostic significance of triglyceride-glucose index in acute coronary syndrome patients without standard modifiable cardiovascular risk factors.Cardiovascular diabetology · 2024Observational
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- Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis.Frontiers in nutrition · 2024Article
- Weight Loss Supplements.Molecules (Basel, Switzerland) · 2023Review
- Machine learning-based models to predict one-year mortality among Chinese older patients with coronary artery disease combined with impaired glucose tolerance or diabetes mellitus.Cardiovascular diabetology · 2023Article
- Regulation of cardiovascular health and disease by visceral adipose tissue-derived metabolic hormones.The Journal of physiology · 2023Article
- The Association between High-Sensitivity C-Reactive Protein and Metabolic Syndrome in an Elderly Population Aged 50 and Older in a Community Receiving Primary Health Care in Taiwan.International journal of environmental research and public health · 2022Article
- Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases.Pharmaceutics · 2022Review
- Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China.Cardiovascular diabetology · 2022Article
- Evaluation of the long-term prognostic ability of triglyceride-glucose index for elderly acute coronary syndrome patients: a cohort study.Cardiovascular diabetology · 2022Article
- Autophagy regulation using luteolin: new insight into its anti-tumor activity.Cancer cell international · 2020Review
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- Dyslipidemia: A Trigger for Coronary Heart Disease in Romanian Patients with Diabetes.Metabolites · 2020Article
- Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020Article
- Effect of stress hyperglycaemia on monocyte chemoattractant protein-1 levels and the short-term prognosis of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.Experimental and therapeutic medicine · 2019Article
- Targeting Autophagy to Overcome Human Diseases.International journal of molecular sciences · 2019Review
- Relationship between Adipocytokines, Nontraditional Anthropometric Indices and Coronary Heart Disease Risk in Diabetic Patients.Current health sciences journalArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease (CHD) was investigated. Clinical data of 72 patients with diabetes mellitus diagnosed in Weifang People's Hospital (Weifang, China) from October 2015 to January 2017 were retrospectively analyzed. Thirty patients were combined with CHD and 42 patients were not. There were 43 males and 29 females. General information and clinical data including age, sex, duration of diabetes mellitus, biochemical indicators, fasting insulin levels, CRP, insulin resistance index, arterial lesions of coronary angiography and Gensini scores were collected. The levels of FINS, FPG, HOMA-R and CPR were significantly higher, and the level of ADPN was significantly lower in diabetes complicated with CHD group than that without CHD group (P<0.05). Incidence of single coronary artery disease and mild coronary lesion were significantly lower, and incidences of double and triple lesions were significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05). Gensini score was significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05); Analysis of the correlation showed that CRP (r=0.422, P=0.001) and insulin resistance index (r=0.828, P=0.001) were positively correlated with Gensini score, while the adiponectin level was negatively correlated with Gensini score (r= -0.719, P<0.001). Logistic regression analysis showed that FINS, ADPN, HOMA-R, CPR, duration of diabetes mellitus and BMI had independently predictive value for diabetes complicated with CHD (P<0.05). Serum adiponectin, insulin resistance and CPR levels are closely related to diabetes mellitus combined with coronary heart disease, and can affect the degree of vascular endothelial injury in coronary heart disease.
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