ArticleNeural plasticity2018
Functional Connectivity Alterations in Children with Spastic and Dyskinetic Cerebral Palsy.
Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Robot-assisted gait training improves walking and cerebral connectivity in children with unilateral cerebral palsy.Pediatric research · 2024Trial
- Safety and efficacy outcomes after intranasal administration of neural stem cells in cerebral palsy: a randomized phase 1/2 controlled trial.Stem cell research & therapy · 2023Trial
- Trial
- Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation.bioRxiv : the preprint server for biology · 2026Article
- Individualized electrode subset improves the calibration accuracy of an EEG P300-design brain-computer interface for people with severe cerebral palsy.Frontiers in human neuroscience · 2026Article
- Exploring communication impairments in children with spastic cerebral palsy through neurovascular coupling: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.Quantitative imaging in medicine and surgery · 2025Article
- Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review.Developmental medicine and child neurology · 2025Article
- Brain functional connectivity and activity during motor control in children with cerebral palsy: a pilot cross-sectional fNIRS study.Translational pediatrics · 2025Article
- Dynamic Task-Related Changes in Electroencephalography Brain Connectivity During a Button-Press Task in Children with and Without Bilateral Cerebral Palsy.Brain connectivity · 2025Article
- Thalamic deep brain stimulation improves movement in a cerebellar model of lesion-based status dystonicus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury.Neurology. Clinical practice · 2025Article
- Lesion distribution and network mapping in dyskinetic cerebral palsy.Brain communications · 2025Article
- Targeting DBS to the centrolateral thalamic nucleus improves movement in a lesion-based model of acquired cerebellar dystonia in mice.bioRxiv : the preprint server for biology · 2024Article
- Denoising brain networks using a fixed mathematical phase change in independent component analysis of magnitude-only fMRI data.Human brain mapping · 2023Article
- Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias.Dystonia (Lausanne, Switzerland) · 2023Article
- Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy.Frontiers in neurology · 2023Article
- Aberrant static and dynamic functional network connectivity in heart failure with preserved ejection fraction.ESC heart failure · 2022Article
- Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity.Brain topography · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunctional characteristics between SCP and DCP on the brain network level are less known. This study aims to detect the alteration of brain functional connectivity in children with SCP and DCP based on resting-state functional MRI (fMRI). Resting-state networks (RSNs) were established based on the independent component analysis (ICA), and the functional network connectivity (FNC) was performed on the fMRI data from 16 DCP, 18 bilateral SCP, and 18 healthy children. Compared with healthy controls, altered functional connectivity within the cerebellum network, sensorimotor network (SMN), left frontoparietal network (LFPN), and salience network (SN) were found in DCP and SCP groups. Furthermore, the disconnections of the FNC consistently focused on the visual pathway; covariance of the default mode network (DMN) with other networks was observed both in DCP and SCP groups, while the DCP group had a distinct connectivity abnormality in motor pathway and self-referential processing-related connections. Correlations between the functional disconnection and the motor-related clinical measurement in children with CP were also found. These findings indicate functional connectivity impairment and altered integration widely exist in children with CP, suggesting that the abnormal functional connectivity is a pathophysiological mechanism of motor and cognitive dysfunction of CP.
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