ArticleFrontiers in microbiology2018
Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Beyond Infection: The Interplay of Salivary Human Herpesvirus 6, Stress, and Host Factors in Major Depressive Disorder.Viruses · 2026Article
- Review
- Analysis Of Salivary Herpesviruses Reveals Associations Between HHV-6 And Long COVID Severity.medRxiv : the preprint server for health sciences · 2026Article
- Donepezil ameliorates fatigue and depression in PASC patients with HHV-6B SITH-1-induced acetylcholine deficiency.Frontiers in pharmacology · 2026Article
- Association Between Plasma SITH-1 Antibody Titers and Treatment Trajectory of Treatment-Resistant Depression.Neuropsychopharmacology reports · 2025Article
- Viewing Psychiatric Disorders Through Viruses: Simple Architecture, Burgeoning Implications.Neuroscience bulletin · 2025Review
- Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence.International journal of molecular sciences · 2025Review
- HHV-6 reactivations in immunocompetent patients with psychiatric disorders: visual hallucinations or possible interactions?Infectious diseases & immunity · 2025Article
- Exploring the link between burning mouth syndrome and human herpesvirus-6B: a narrative review on pathogenesis.Journal of the Royal Society of New Zealand · 2025Review
- Review
- Identification of a strong genetic risk factor for major depressive disorder in the human virome.iScience · 2024Article
- A single immunization with core-shell structured lipopolyplex mRNA vaccine against rabies induces potent humoral immunity in mice and dogs.Emerging microbes & infections · 2023Article
- The Association of HHV-6 and theViruses · 2023Article
- Review
- No Increased Detection of Nucleic Acids of CNS-related Viruses in the Brains of Patients with Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorder.Schizophrenia bulletin · 2023Article
- A missing link in affect regulation: the cerebellum.Social cognitive and affective neuroscience · 2022Review
- Association between human herpesvirus 6 (HHV-6) and cognitive function in the elderly population in Shenzhen, China.Aging clinical and experimental research · 2022Article
- Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.Clinical neuropsychiatry · 2022Article
- Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells.Frontiers in immunology · 2022Article
- Tissue specific signature of HHV-6 infection in ME/CFS.Frontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can later be activated causing cognitive and behavioral disturbances. Hence, this study was designed to evaluate possible association of HHV-6A and HHV-6B activation with three different groups of psychiatric patients. DNA qPCR, immunofluorescence and FISH studies were carried out in post-mortem posterior cerebellum from 50 cases each of bipolar disorder (BPD), schizophrenia, 15 major depressive disorder (MDD) and 50 appropriate control samples obtained from two well-known brain collections (Stanley Medical Research Institute). HHV-6A and HHV-6B late proteins (indicating active infection) and viral DNA were detected more frequently (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.