Evidence map›Paper›PMID 30186246›Full record

ArticleFrontiers in microbiology2018

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular

Karen Santos, Pradeep B Lukka, Anne Grzegorzewicz, Mary Jackson, Ashit Trivedi, Fernando Pavan, Marlus Chorilli, Miriam Braunstein, Anthony Hickey, Bernd Meibohm and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Nano-Delivery System of Ethanolic Extract of Propolis TargetingNanomaterials (Basel, Switzerland) · 2023
    Article
  4. Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Karen SantosMycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.
Pradeep B LukkaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, United States.
Anne GrzegorzewiczMycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.
Ashit TrivediDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, United States.
Fernando PavanSchool of Pharmaceutical Sciences, São Paulo State University, São Paulo, Brazil.
Marlus ChorilliSchool of Pharmaceutical Sciences, São Paulo State University, São Paulo, Brazil.
Miriam BraunsteinDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Anthony HickeyDiscovery Science and Technology, RTI International, Durham, NC, United States.
Bernd MeibohmDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, United States.
Mercedes Gonzalez-JuarreroMycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.
Colorado State University · USUniversidade Estadual Paulista (Unesp) · BRUniversity of Tennessee Health Science Center · USRTI International · USUniversity of North Carolina at Chapel Hill · US

Funding

Aerosol spectinamide-1599 therapy against tuberculosisR01AI120670 · NIAID · COLORADO STATE UNIVERSITY · PI BRAUNSTEIN, MIRIAM S., GONZALEZ-JUARRERO, MERCEDES · 2016 to 2020
$3.6M
Mass Spectrometer for Small Molecule Drug DevelopmentS10OD016226 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MEIBOHM, BERND · 2014 to 2014
$316k
NIAID NIH HHS R01 AI120670NIH HHS S10 OD016226
6 · The paper itself

Abstract

There is an urgent need to treat tuberculosis (TB) quickly, effectively and without side effects.

Indexed as

dendritic cellsGM-CSFinterferonintracellularlungMycobacterium-tuberculosispyrazinamidespectinamides

Identifiers

PMID30186246
PMCPMC6110900
OpenAlexW2888223751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.