ReviewFrontiers in pharmacology2018
The Role of Vitamin E in Preventing and Treating Osteoarthritis - A Review of the Current Evidence.
Review in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Assessment of vitamin E status among patients with newly diagnosed primary knee osteoarthritis in Cameroon.Scientific reports · 2026Article
- Dietary vitamin E intake and all-cause mortality in patients with osteoarthritis: a prospective cohort study using NHANES data.European journal of medical research · 2025Article
- Evaluation of Vitamin E in Trauma and Orthopaedics: A Narrative Synthesis.Indian journal of orthopaedics · 2025Review
- The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases.Journal of inflammation research · 2025Review
- A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment.Redox biology · 2024Article
- Association between Dietary total antioxidant capacity and knee osteoarthritis: a case-control study in the Iranian Population.BMC musculoskeletal disorders · 2024Article
- No genetic causal association between circulating alpha-tocopherol levels and osteoarthritis, a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Pt-Se Hybrid Nanozymes with Potent Catalytic Activities to Scavenge ROS/RONS and Regulate Macrophage Polarization for Osteoarthritis Therapy.Research (Washington, D.C.) · 2024Article
- Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity.International journal of molecular sciences · 2023Review
- The Role of Nutrition in Osteoarthritis Development.Nutrients · 2023Article
- Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies.Nature reviews. Rheumatology · 2023Review
- Associations between clinically diagnosed medical conditions and dietary supplement use: the US military dietary supplement use study.Public health nutrition · 2023Article
- The Role of Tocotrienol in Arthritis Management-A Scoping Review of Literature.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature.Antioxidants (Basel, Switzerland) · 2023Review
- Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.Frontiers in bioengineering and biotechnology · 2023Article
- Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing.Frontiers in pharmacology · 2023Review
- Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.Current osteoporosis reports · 2022Review
- Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review.Drugs & aging · 2022Review
- Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial.Journal of nutrition and metabolism · 2022Article
- Radioprotective Role of Vitamins C and E against the Gamma Ray-Induced Damage to the Chemical Structure of Bovine Serum Albumin.Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is a debilitating disease of the joint involving cartilage degeneration and chondrocytes apoptosis. Oxidative stress is one of the many proposed mechanisms underpinning joint degeneration in osteoarthritis. The current pharmacotherapies emphasize pain and symptomatic management of the patients but do not alter the biological processes underlying the cartilage degeneration. Vitamin E is a potential agent to prevent or treat osteoarthritis due to its antioxidant and anti-inflammatory effects. This review aims to summarize the current evidence on the relationship between vitamin E and osteoarthritis derived from preclinical and human studies. Cellular studies showed that vitamin E mitigated oxidative stress in cartilage explants or chondrocyte culture invoked by mechanical stress or free radicals. Animal studies suggested that vitamin E treatment prevented cartilage degeneration and improve oxidative status in animal models of osteoarthritis. Low circulating or synovial vitamin E was observed in human osteoarthritic patients compared to healthy controls. Observational studies also demonstrated that vitamin E was related to induction or progression of osteoarthritis in the general population. Vitamin E supplementation might improve the outcomes in patients with osteoarthritis, but negative results were also reported. Different isomers of vitamin E might possess distinct anti-osteoarthritic effects. As a conclusion, vitamin E may retard the progression of osteoarthritis by ameliorating oxidative stress and inflammation of the joint. Further studies are warranted to develop vitamin E as an anti-osteoarthritis agent to reduce the global burden of this disease.
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